herb

Black Seed Oil

Also known as Nigella sativa, Black cumin seed oil

Oil pressed from Nigella sativa seeds; its active compound thymoquinone has shown anti-inflammatory and antioxidant activity in trials, and is studied for metabolic, respiratory, and immune outcomes.

Reported side effects:Allergic contact dermatitis reported with repeated topical application of black seed oil (skin contact route); oral-trial meta-analyses did not report this

Be careful if: pregnant

Ask first if you take: diabetes medicines, including insulin, blood-pressure medicines

Suspect a side effect? Report it to the MHRA Yellow Card scheme ↗

2linked conditions

14linked studies

On this pageWhat studies found Safety Evidence Availability Outcomes & conditions →

Evidence

What the research actually shows

We link to relevant studies and leave interpretation to you and your healthcare professional.

What studies found

The headline results, condition by condition

The large figures are what the studies reported for each thing they measured. Open a card for every result.

Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.

Inflammation

23 of 30 results reported a benefit

5 studies, including a review of trials

Inflammation marker (CRP)No clear difference0.98 mg/L lower1 review of trials2 of 4 results reported a benefit2021 study ↗
Inflammation marker (TNF-alpha)2.15 pg/mLlower1 review of trials3 of 4 results reported a benefit2021 study ↗
Inflammation marker (IL-6)No clear difference0.25 pg/mL lower1 review of trials1 of 2 results reported a benefit2021 study ↗

Also measured alongside: 'Bad' (LDL) cholesterol (reported a benefit); Fasting blood sugar (reported a benefit); Long-term blood sugar (HbA1c) (reported a benefit); and 7 more.

Every result

Safety

Safety and considerations

What sources report about side effects, who should be careful, and medicines to ask about first.

Reported side effects

Reported effect	How often	Basis	Sources
Allergic contact dermatitis reported with repeated topical application of black seed oil (skin contact route); oral-trial meta-analyses did not report this	unknown	Listed by PubMed corpus rows (PubMed 36494318)	Assier H, et al. Severe allergic contact connubial dermatitis to Nigella Sativa Seed Oil due to repeated contacts to beard cosmetics. Contact Dermatitis 2023;88(3):245-246 (PMID 36494318)

Serious effects reported

Reported effect	How often	Basis	Sources
A single published case report describes DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) after topical use of black cumin seed oil; no oral-trial cases located	unknown	Listed by PubMed corpus rows (PubMed 35419842)	Fargeas M, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after topical use of Nigella sativa (black cumin) oil. Contact Dermatitis 2022;87(2):203-204 (PMID 35419842)

Be careful if you…

Applies to	What sources say	Sources
pregnant	No pregnancy safety data for oral supplementation found in the sources checked: no UK SmPC, BNF/NICE, NHS, NIH ODS or EMA HMPC entry exists, and the 15-trial paediatric review and 31-trial meta-analyses excluded pregnancy. Ask a clinician before use in pregnancy.	Abumadini MM, et al. Clinical Uses of Nigella Sativa in Pediatrics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Pediatr Pharmacol Ther 2025;30(5):580-592 (PMID 41112345)

Medicines to ask about

Severity	Medicine	Sources
caution	diabetes medicines, including insulin — Supplementation itself lowered fasting glucose by around 19 mg/dL and HbA1c by about 0.6 in a 31-trial meta-analysis of people with metabolic disease. No formal drug-interaction trials were located; people on diabetes medicines should watch for additional glucose lowering and tell their clinician.	Musazadeh V, et al. The Effect of Nigella sativa Supplementation on Cardiometabolic Health in Patients With Metabolic Diseases: A GRADE-Assessed Systematic Review and Meta-Analysis. Endocrinol Diabetes Metab 2026;9(2):e70207 (PMID 41858302)
caution	blood-pressure medicines — Supplementation lowered systolic blood pressure by around 3 mmHg and diastolic by around 3 mmHg in a 31-trial meta-analysis, and a dedicated meta-analysis of randomised trials reports the same direction of effect on blood pressure. Additive lowering with blood-pressure medicines is possible - monitor.	Musazadeh V, et al. The Effect of Nigella sativa Supplementation on Cardiometabolic Health in Patients With Metabolic Diseases: A GRADE-Assessed Systematic Review and Meta-Analysis. Endocrinol Diabetes Metab 2026;9(2):e70207 (PMID 41858302)Sahebkar A, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens 2016;34(11):2127-2135 (PMID 27512971)

How much is too much

Stacking flags: lowers blood sugar, lowers blood pressure

Sources

Musazadeh V, et al. The Effect of Nigella sativa Supplementation on Cardiometabolic Health in Patients With Metabolic Diseases: A GRADE-Assessed Systematic Review and Meta-Analysis. Endocrinol Diabetes Metab 2026;9(2):e70207 (PMID 41858302)Sahebkar A, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens 2016;34(11):2127-2135 (PMID 27512971)Abumadini MM, et al. Clinical Uses of Nigella Sativa in Pediatrics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Pediatr Pharmacol Ther 2025;30(5):580-592 (PMID 41112345)Fargeas M, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after topical use of Nigella sativa (black cumin) oil. Contact Dermatitis 2022;87(2):203-204 (PMID 35419842)Assier H, et al. Severe allergic contact connubial dermatitis to Nigella Sativa Seed Oil due to repeated contacts to beard cosmetics. Contact Dermatitis 2023;88(3):245-246 (PMID 36494318)LiverTox [Internet]. Black Cumin Seed chapter. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases, NIH; 2012- (retrieved 2026-10-16)

Evidence analytics

Where the evidence is concentrated

Audited published research for Black Seed Oil by condition. Drill into a pair page for the full breakdown.

Published research

Black Seed Oil: findings by condition

What this means: Bars count reported findings, not treatment effectiveness or certainty.

One study may report several findings or appear in more than one pairing. Counts do not show the size of an effect. Comparable numerical estimates are not established for this summary.

View the full data table

Published research: reported directions by pairing
Compound and condition	Findings (count)	Studies (count)	Reported results (finding counts)	How sure?
Inflammation	30	5	Benefit: 23; no benefit: 7; harm: 0; unclear: 0; not recorded / unrecognised: 0	Not formally graded

Suggested uses (unproven)

Where people report using it and what trials suggest

Moderate evidenceFasting glucose / HbA1c
Moderate evidenceLDL & total cholesterol
Moderate evidenceBlood pressure (small reduction)
Weak evidenceAsthma symptoms adjunct

Where the evidence is negative

Common claims the trials do not support

Meta-analysis quality limited: small samples, mostly Middle-Eastern centres, short duration.
Weight-loss effect trivial (<1 kg).

Nigella sativa oil (thymoquinone) with consistent but small-trial metabolic improvements; effect sizes modest, quality moderate.

Evidence grades reflect study quality and consistency, not marketing claims.

14studies referenced

13journals

1999–2025publication range

Ordered by strength of evidence, then result direction.

01Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysisGhobadi H, et al. · Inflammopharmacology · 2025PMID 40839182 ↗02Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled TrialsHosseini H, et al. · Current pharmaceutical biotechnology · 2024PMID 37859312 ↗03The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trialsKavyani Z, et al. · Inflammopharmacology · 2023PMID 37036558 ↗04The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trialsMontazeri RS, et al. · Journal of food biochemistry · 2021PMID 33559935 ↗05The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysisMalekian S, et al. · Journal of complementary & integrative medicine · 2021PMID 34187123 ↗06Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus: A reviewMohebbati R, et al. · Journal of ethnopharmacology · 2020PMID 31972323 ↗

Show all 14 studies

07A Systematic Review of the Potential Effects of Nigella sativa on Rheumatoid ArthritisKhabbazi A, et al. · Planta medica · 2020PMID 32274788 ↗08Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trialsHallajzadeh J, et al. · Phytotherapy research : PTR · 2020PMID 32394508 ↗09Effect of Nigella sativa L. supplementation on inflammatory and oxidative stress indicators: A systematic review and meta-analysis of controlled clinical trialsMohit M, et al. · Complementary therapies in medicine · 2020PMID 33183658 ↗10A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese womenRazmpoosh E, et al. · BMC complementary medicine and therapies · 2024PMID 38178093 ↗11Effect of Nigella sativa on general health and immune system in young healthy volunteers; a randomized, placebo-controlled, double-blinded clinical trialSalem A, et al. · F1000Research · 2021PMID 37901256 ↗12Black currant seed oil supplementation of mothers enhances IFN-γ and suppresses IL-4 production in breast milkLinnamaa P, et al. · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013PMID 23980846 ↗13Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extractDirjomuljono M, et al. · International journal of clinical pharmacology and therapeutics · 2008PMID 18541126 ↗14Effect of dietary supplementation with black currant seed oil on the immune response of healthy elderly subjectsWu D, et al. · The American journal of clinical nutrition · 1999PMID 10500023 ↗

Search PubMed ↗View on PubChem ↗Find clinical trials ↗

Published research results

Reported results grouped by condition. Values and units are preserved as recorded; missing information is not estimated.

How to read this table

Benefit: What the trial saw happen: whether the measured outcome moved in the helpful direction in that one study (the tag on each row: “Benefit seen”, “No clear benefit”, “Possible harm” or “Unclear”). It is a study result — not advice, and not a promise it will work for you.
Evidence: Study design describes how research was conducted. It is not a formal certainty assessment.
Effect size: The result recorded in this summary. “Not reported” means the value is missing from the summary; it does not establish that the publication omitted it.

Reported direction, numerical results and study design are separate. Certainty has not been formally graded in this table.

Inflammation (30 outcomes)

Published research: Inflammation
What was measured	Reported findings	Result and units	Reported sample and duration	Study / source
glutathione peroxidase (GPx)	GPx levels significantly improved by SMD 1.23 in 1086 participants compared to control. (95% CI 0.25, 2.22; p=0.014)Benefit seen	1.23 SMD Recorded unit: Not reported	Sample (as reported): 1086 Follow-up: Not reported	Meta-analysis · 2023 Study details The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 37036558
superoxide dismutase (SOD)	SOD levels significantly improved by SMD 2.05 in 1086 participants compared to control. (95% CI 1.22, 2.88, p<0.001)Benefit seen	2.05 SMD Recorded unit: Not reported	Sample (as reported): 1086 Follow-up: Not reported	Meta-analysis · 2023 Study details The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 37036558
total antioxidant capacity (TAC)	TAC levels significantly improved by SMD 2.28 in 1086 participants compared to control. (95% CI 1.29, 3.27, p<0.001)Benefit seen	2.28 SMD Recorded unit: Not reported	Sample (as reported): 1086 Follow-up: Not reported	Meta-analysis · 2023 Study details The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 37036558
high-sensitivity C-reactive protein (hs-CRP)	hs-CRP levels decreased by 0.67 units compared to control in a meta-analysis of 10 trials. (95% CI: -1.29, -0.05)Benefit seen	-0.67 Recorded unit: Not reported	Sample (as reported): Not reported Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 33559935
malondialdehyde (MDA)	MDA levels decreased by 1.18 units compared to control in a meta-analysis of 10 trials. (95% CI: -2.24, -0.12)Benefit seen	-1.18 Recorded unit: Not reported	Sample (as reported): Not reported Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 33559935
superoxide dismutase (SOD)	SOD levels increased by 66.30 units compared to control in a meta-analysis of 10 trials. (95% CI: 1.03, 131.57)Benefit seen	66.30 Recorded unit: Not reported	Sample (as reported): Not reported Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 33559935
total antioxidant capacity (TAC)	TAC levels increased by 0.35 units compared to control in a meta-analysis of 10 trials. (95% CI: 0.10, 0.59)Benefit seen	0.35 Recorded unit: Not reported	Sample (as reported): Not reported Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 33559935
tumor necrosis factor-alpha (TNF-α)	TNF-α levels decreased by 2.29 units compared to control in a meta-analysis of 10 trials. (95% CI: -4.48, -0.11)Benefit seen	-2.29 Recorded unit: Not reported	Sample (as reported): Not reported Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Meta-Analysis PMID 33559935
high sensitivity C-reactive protein	No significant difference in high sensitivity C-reactive protein vs placebo or no supplementation in 267 participants. (95% CI=-1.98-0.03)No clear benefit	Not reported Recorded unit: mg/L	Sample (as reported): 267 Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis. Meta-Analysis PMID 34187123
Interleukin 6 (IL-6)	No significant difference in Interleukin 6 vs placebo or no supplementation in 134 participants. (95% CI=-0.65 to 0.16)No clear benefit	Not reported Recorded unit: pg/mL	Sample (as reported): 134 Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis. Meta-Analysis PMID 34187123
malondialdehyde	No significant difference in malondialdehyde vs placebo or no supplementation in 179 participants. (95% CI=-1.97-0.08)No clear benefit	Not reported Recorded unit: nmol/mL	Sample (as reported): 179 Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis. Meta-Analysis PMID 34187123
superoxide dismutase	Superoxide dismutase levels increased by 63.79 µ/gHb vs placebo or no supplementation in 88 participants. (95% CI=6.84-120.75)Benefit seen	63.79 µ/gHb Recorded unit: µ/gHb	Sample (as reported): 88 Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis. Meta-Analysis PMID 34187123
total antioxidant capacity	Total antioxidant capacity increased by 0.34 mmol/L vs placebo or no supplementation in 232 participants. (95% CI=0.04 to 0.63)Benefit seen	0.34 mmol/L Recorded unit: mmol/L	Sample (as reported): 232 Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis. Meta-Analysis PMID 34187123
Tumor Necrosis Factor alpha (TNF-α)	TNF-α levels decreased by 2.15 pg/mL vs placebo or no supplementation in 262 participants. (95% CI=-3.22--1.09)Benefit seen	-2.15 pg/mL Recorded unit: pg/mL	Sample (as reported): 262 Follow-up: Not reported	Meta-analysis · 2021 Study details The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis. Meta-Analysis PMID 34187123
CRP	No significant benefit found for CRP vs control in 50 trials. (95% CI: -9.23, 2.01)No clear benefit	Not reported Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
fasting glucose	Fasting glucose reduced by 15.18 vs control in 50 trials. (95% CI: -19.82, -10.55)Benefit seen	-15.18 Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
HbA1C levels	HbA1C levels reduced by 0.45 vs control in 50 trials. (95% CI: -0.66, -0.23)Benefit seen	-0.45 Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
LDL-cholesterol	LDL-cholesterol reduced by 18.45 vs control in 50 trials. (95% CI: -22.44, -14.94)Benefit seen	-18.45 Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
MDA levels	No significant benefit found for MDA levels vs control in 50 trials. (95% CI: -2.18, 0.27)No clear benefit	Not reported Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
TAC	No significant benefit found for TAC vs control in 50 trials. (95% CI: 0.00, 0.63)No clear benefit	Not reported Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
TNF-α	No significant benefit found for TNF-α vs control in 50 trials. (95% CI: -3.23, 0.86)No clear benefit	Not reported Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
total cholesterol	Total cholesterol reduced by 16.80 vs control in 50 trials. (95% CI: -21.04, -12.55)Benefit seen	-16.80 Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
triglycerides	Triglycerides reduced by 15.73 vs control in 50 trials. (95% CI: -20.77, -10.69)Benefit seen	-15.73 Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
VLDL-cholesterol	VLDL-cholesterol reduced by 3.72 vs control in 50 trials. (95% CI: -7.27, -0.18)Benefit seen	-3.72 Recorded unit: Not reported	Sample (as reported): 50 trials Follow-up: Not reported	Meta-analysis · 2020 Study details Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Meta-Analysis PMID 32394508
CRP	CRP levels decreased by SMD -0.60 vs placebo in 1033 people. (95% CI: from -0.96 to -0.23; P = 0.00)Benefit seen	-0.60 SMD Recorded unit: Not reported	Sample (as reported): 1033 Follow-up: Not reported	Systematic review · 2024 Study details Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Systematic Review PMID 37859312
IL-6	IL-6 levels decreased by SMD -0.54 vs placebo in 1033 people. (95% CI: from -1.01 to -0.07; P = 0.02)Benefit seen	-0.54 SMD Recorded unit: Not reported	Sample (as reported): 1033 Follow-up: Not reported	Systematic review · 2024 Study details Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Systematic Review PMID 37859312
MDA	MDA levels decreased by SMD -1.28 vs placebo in 1033 people. (95% CI: from -2.11 to -0.46; P = 0.00)Benefit seen	-1.28 SMD Recorded unit: Not reported	Sample (as reported): 1033 Follow-up: Not reported	Systematic review · 2024 Study details Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Systematic Review PMID 37859312
SOD	SOD levels increased by SMD 1.35 vs placebo in 1033 people. (95% CI, from 0.77 to 1.93; P = 0.00)Benefit seen	1.35 SMD Recorded unit: Not reported	Sample (as reported): 1033 Follow-up: Not reported	Systematic review · 2024 Study details Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Systematic Review PMID 37859312
TAC	TAC levels increased by SMD 2.82 vs placebo in 1033 people. (95% CI, from 0.55 to 5.084; P = 0.01)Benefit seen	2.82 SMD Recorded unit: Not reported	Sample (as reported): 1033 Follow-up: Not reported	Systematic review · 2024 Study details Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Systematic Review PMID 37859312
TNF-α	TNF-α levels decreased by SMD -0.53 vs placebo in 1033 people. (95% CI: from -0.74 to -0.53; P = 0.00)Benefit seen	-0.53 SMD Recorded unit: Not reported	Sample (as reported): 1033 Follow-up: Not reported	Systematic review · 2024 Study details Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Systematic Review PMID 37859312

Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.

Outcomes & conditions

Why people look into Black Seed Oil — and what they report

Associated conditions and community-reported outcomes, wrapped together on one page. Aggregates appear only once enough reports arrive.

Outcomes & conditions →

Availability

Where to get Black Seed Oil (UK)

How this compound is sold in the UK, and where our readers typically find it.

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