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Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Fat-soluble vitamin synthesised in skin from UVB exposure and activated by the liver and kidneys; regulates calcium and phosphate absorption for bone health and modulates immune and mood pathways via vitamin D receptors.
Adaptogenic root herb whose withanolide compounds are thought to blunt HPA-axis cortisol release; clinical trials link standardised extracts to reduced perceived stress and anxiety scores.
Magnesium chelated to the amino acid glycine for better gut tolerance and absorption than inorganic salts; magnesium is a cofactor in over 300 enzyme reactions governing nerve transmission, muscle relaxation, and sleep.
Long-chain polyunsaturated fatty acids from fish or algal oil that are incorporated into cell membranes and reduce pro-inflammatory eicosanoid production; linked to cardiovascular, joint, and neurological benefits.
Compound stored in skeletal muscle as phosphocreatine, buffering ATP regeneration during short, high-intensity effort; one of the most extensively studied ergogenic supplements for strength and lean mass.
Amino acid from tea leaves that crosses the blood-brain barrier and increases alpha-wave brain activity; promotes calm alertness without sedation, often paired with caffeine.
Hormone released by the pineal gland in response to darkness that signals circadian phase to the brain's suprachiasmatic nucleus; low-dose supplementation can shorten time to fall asleep and ease jet lag.
Essential trace mineral and cofactor for over 300 enzymes; supports immune cell function, wound healing, and testosterone synthesis, with topical and oral forms used for acne.
Non-intoxicating cannabinoid that modulates the endocannabinoid system indirectly and acts on serotonin 5-HT1A receptors; studied for anxiety, inflammatory pain, and sleep disruption.
Live microorganisms, commonly Lactobacillus and Bifidobacterium strains, that colonise the gut and influence digestion and immune signalling via short-chain fatty acid production; effects are strain- and dose-specific.
Adaptogenic root native to arctic Scandinavia and Siberia; its rosavins and salidroside are thought to modulate cortisol and monoamine activity, with trials showing reduced fatigue and improved stress resilience.
Medicinal mushroom containing hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis in animal models; studied in humans for mild cognitive impairment and mood.
Water-soluble vitamin required for red blood cell formation, myelin synthesis, and DNA production; deficiency, common in older adults and vegans, causes fatigue and neurological symptoms that supplementation corrects.
Water-soluble antioxidant vitamin and essential cofactor for collagen synthesis and non-haem iron absorption; supports immune cell function and skin integrity, and cannot be made by the human body.
Essential mineral forming the oxygen-binding core of haemoglobin and myoglobin; supplementation corrects iron-deficiency anaemia, a common cause of fatigue, particularly in menstruating women.
Curcuminoid compounds from turmeric root that inhibit NF-κB and COX-2 inflammatory pathways; poorly absorbed alone, so formulations often add piperine or fats to improve bioavailability for joint pain.
Rhizome containing gingerols and shogaols that inhibit prostaglandin synthesis and act on gut serotonin receptors; well evidenced for nausea, including pregnancy- and chemotherapy-related, and mild anti-inflammatory effects.
Herb used since antiquity as a sedative; its valerenic acid is thought to modulate GABA-A receptors, though clinical evidence for reducing time to fall asleep is mixed.
Extract standardised for flavonoid glycosides and terpene lactones from one of the oldest living tree species; proposed to improve cerebral blood flow and act as an antioxidant, studied for cognitive symptoms and tinnitus.
Ayurvedic herb whose bacosides are thought to enhance dendritic branching and cholinergic signalling; trials of standardised extract taken for 8-12 weeks show modest improvements in memory recall.
Spice from the stigmas of Crocus sativus; its crocin and safranal compounds inhibit serotonin, dopamine, and noradrenaline reuptake, with small trials showing effects on mild-to-moderate depression comparable to low-dose SSRIs.
Fat-soluble compound essential to mitochondrial ATP production and antioxidant defence; levels decline with age and statin use, so supplementation is studied for statin-associated muscle symptoms and cardiovascular support.
Berry extract that inhibits 5-alpha-reductase, the enzyme converting testosterone to DHT; used for benign prostatic hyperplasia symptoms and androgenic hair thinning, though large trials show mixed results versus placebo.
Amino sugar naturally present in cartilage, used as a substrate for glycosaminoglycan synthesis; sulfate-bound formulations have the strongest trial evidence for slowing osteoarthritis symptom progression over months of use.
Organic sulphur compound providing a bioavailable sulphur source for collagen and keratin synthesis; studied for joint pain, exercise-induced muscle soreness, and allergy symptoms, usually alongside glucosamine.
Isoquinoline plant alkaloid that activates AMP-activated protein kinase (AMPK); trials show blood-glucose-lowering effects in type 2 diabetes approaching those of metformin, though GI side effects are common.
Full-spectrum ashwagandha root extract standardised for withanolide content using a low-temperature aqueous extraction process; the most heavily trialled ashwagandha formulation for cortisol reduction and stress resilience.
Legume seed containing furostanolic saponins studied for modest increases in free testosterone and libido in men; used traditionally to support lactation and post-meal blood glucose control.
Concentrated catechin polyphenols from Camellia sinensis, chiefly epigallocatechin gallate (EGCG); modestly increases thermogenesis and fat oxidation when combined with caffeine, and provides broad antioxidant activity.
Direct metabolic precursor to serotonin, derived from Griffonia simplicifolia seeds, bypassing the rate-limiting step in serotonin synthesis; must not be combined with SSRIs, MAOIs, or other serotonergic drugs due to serotonin syndrome risk.
Acetylated form of the amino acid cysteine and the rate-limiting precursor for glutathione, the body's principal antioxidant; used clinically as the antidote for paracetamol overdose and studied for respiratory and mental health.
Choline compound that crosses the blood-brain barrier efficiently and is metabolised to free choline, a building block for acetylcholine; studied for cognitive performance and, at higher doses, acute power output in training.
Non-essential amino acid and precursor to dopamine and noradrenaline via the enzyme tyrosine hydroxylase; most consistent evidence is for preserving cognitive performance under acute stress, sleep loss, or cold exposure rather than baseline mood.
Phospholipid concentrated in neuronal cell membranes, now typically sourced from soy or sunflower lecithin; small trials suggest a reduced cortisol response to exercise stress and modest cognitive benefit in age-related decline.
Hydrolysed collagen protein broken into short peptides for absorption; provides glycine and proline as substrate for the body's own collagen synthesis, with trials showing improved skin elasticity and joint comfort after 8-12 weeks.
Glycosaminoglycan naturally present in skin, joint synovial fluid, and connective tissue, capable of binding many times its weight in water; oral and injectable forms are studied for skin hydration and joint lubrication.
Parasitic fungus traditionally harvested at high altitude in Tibet and now commonly cultivated; proposed to increase cellular ATP production and oxygen utilisation, studied for exercise endurance and libido.
Polypore fungus containing triterpenes and beta-glucans studied for immunomodulatory and calming effects; used traditionally in East Asian medicine to support sleep and reduce stress.
Mineral-rich resin exuded from rock in high-altitude ranges including the Himalayas, containing fulvic acid and trace minerals; studied for testosterone support, fatigue, and as a nutrient-absorption enhancer.
Oil pressed from Nigella sativa seeds; its active compound thymoquinone has shown anti-inflammatory and antioxidant activity in trials, and is studied for metabolic, respiratory, and immune outcomes.
Sugar alcohol, not a true vitamin, involved in insulin signal transduction and cell membrane structure; myo-inositol is well studied for improving insulin sensitivity and ovulation in PCOS, and for reducing panic and anxiety symptoms.
Sulphonic beta-amino acid abundant in cardiac and skeletal muscle and the central nervous system; involved in bile acid conjugation, osmoregulation, and modulation of GABA/glycine receptors, and studied for cardiovascular and exercise performance.
Delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in Cannabis sativa, acting as a partial agonist at CB1 receptors; used medically for chronic pain, chemotherapy-induced nausea, appetite stimulation, and spasticity. Subject to legal restrictions varying by jurisdiction.
Purified, THC-free cannabidiol in crystalline form; shares CBD Oil's proposed anxiolytic and anti-inflammatory mechanisms without whole-plant entourage compounds, psychoactive effects, or most legal restrictions.
Non-psychoactive cannabinoid from which THC and CBD are enzymatically derived in the cannabis plant; early preclinical research suggests antibacterial, anti-inflammatory, and neuroprotective activity, though human trial data remain limited.
Mildly psychoactive cannabinoid formed as THC oxidises and degrades over time, most concentrated in aged cannabis; marketed for sedative effects, though robust clinical trial evidence for sleep is still lacking.