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Also known as Alpha-glycerylphosphorylcholine
Choline compound that crosses the blood-brain barrier efficiently and is metabolised to free choline, a building block for acetylcholine; studied for cognitive performance and, at higher doses, acute power output in training.
We link to relevant studies and leave interpretation to you and your healthcare professional.
Number of audited published findings for Alpha-GPC by condition. Drill into a pair page for the full breakdown.
Where people report using it and what trials suggest
Common claims the trials do not support
Cholinergic compound with small acute-cognition and stroke-recovery trials (Rx in some countries); consumer nootropic claims outpace data.
Safety notes: Well tolerated; headache/heartburn possible. Caution with scopolamine and AChE inhibitors.
Evidence grades reflect study quality and consistency, not marketing claims.
Summaries of published trial results for this compound, grouped by condition. Numbers are reported exactly as the researchers published them — we never calculate or convert.
How to read this table
In short: benefit is what was observed; evidence is how much you should trust the observation. A “Benefit seen” tag on a weak study counts for far less than the same tag on a meta-analysis.
| Outcome measured | What trials found | Effect size | People studied | Duration | Type of evidence | Study |
|---|---|---|---|---|---|---|
| Psychometric performance in vascular dementia | Alpha-GPC improved most psychometric tests more than cytosine diphosphocholine when compared in vascular dementia; the abstract gives no effect size.Benefit seen | no number reported | 120 | 90 days | RCT · 1991 | PMID 1916007 |
| Attention and memory after scopolamine | Alpha-GPC counteracted scopolamine-related attention and memory impairment compared to placebo pretreatment; the abstract gives no effect size.Benefit seen | no number reported | Thirty-two | ten day | RCT · 1991 | PMID 2071257 |
Associated conditions and community-reported outcomes, wrapped together on one page. Aggregates appear only once enough reports arrive.
How this compound is sold in the UK, and where our readers typically find it.
Retailer search links — we may earn commission on purchases at no cost to you. Commission never affects our evidence ratings.