Alpha-GPC for Memory
Choline compound that crosses the blood-brain barrier efficiently and is metabolised to free choline, a building block for acetylcholine; studied for cognitive performance and, at higher doses, acute power output in training.
Alpha-GPC for Memory
2 of 2 results reported a benefit, from 2 published studies.
2 randomised trials, 120 people · the chart counts everything measured
- 2 reported a benefit
Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.
- Attention and memoryReported a benefitmeasurement not reportedAlpha-GPC counteracted scopolamine-related attention and memory impairment compared to placebo pretreatment.1 randomised trial1991 study ↗
Also measured in these studies (1)
These were measured alongside, but they are not what this condition is about.
- Thinking test performanceReported a benefitmeasurement not reportedAlpha-GPC improved most psychometric tests more than cytosine diphosphocholine when compared in vascular dementia.1 randomised trial1991 study ↗
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every result is listed below.
See every resultThe connection
Short-term memory, recall, and age-related memory decline.
Also known as: Alpha-glycerylphosphorylcholine
Alpha-GPC × Memory: at a glance
Every published result for this pair, extracted and audited.
These charts count reported findings from published studies, grouped by reported benefit and study design. Study design is not a certainty grade.
Alpha-GPC / Memory: reported findings; one study may contribute several findings.
What the evidence shows
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Benefit | 2 |
Study designs behind these findings
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Randomised trial | 2 |
- Studies
- 2
| Study | Outcome | Reported result | Uncertainty (as reported) | Study duration |
|---|---|---|---|---|
| A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. (PMID 1916007) | Psychometric performance in vascular dementia | Not reported | Not reported | 90 days |
| Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. (PMID 2071257) | Attention and memory after scopolamine | Not reported | Not reported | ten day |
Study results, as reported by the publications
Every measured outcome, one row per finding - numbers exactly as reported. Units are preserved where supplied; missing units are not inferred.
| Study and type | Reported sample and duration | Outcome measured | Reported result | What studies found |
|---|---|---|---|---|
| PMID 1916007 1991 Randomised trial | Sample (as reported): 120Duration: 90 days | Psychometric performance in vascular dementia | Not reported | Benefit |
| PMID 2071257 1991 Randomised trial | Sample (as reported): Thirty-twoDuration: ten day | Attention and memory after scopolamine | Not reported | Benefit |
Alpha-GPC × Memory: the evidence base
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysisTiemtad P, et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026PMID 41678913 ↗02Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic ReviewAl Shahab S, et al. · Nutrients · 2025PMID 40362791 ↗03Plant-derived nootropics and human cognition: A systematic reviewLorca C, et al. · Critical reviews in food science and nutrition · 2023PMID 34978226 ↗04Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-AnalysisBonvicini M, et al. · Nutrients · 2023PMID 36678257 ↗05Dietary Flavonoids and Human Cognition: A Meta-AnalysisCheng N, et al. · Molecular nutrition & food research · 2022PMID 35333451 ↗06Application of Citicoline in Neurological Disorders: A Systematic ReviewJasielski P, et al. · Nutrients · 2020PMID 33053828 ↗Community experiences
Contributors volunteered; this does not establish treatment effectiveness or population incidence.
Reported changes
No publishable community breakdown is available. This does not establish that no reports exist.