Supplement

Coenzyme Q10

Also known as CoQ10, Ubiquinone, Ubiquinol

Fat-soluble compound essential to mitochondrial ATP production and antioxidant defence; levels decline with age and statin use, so supplementation is studied for statin-associated muscle symptoms and cardiovascular support.

2linked conditions

19linked studies

On this pageEvidence Availability Outcomes & conditions →

Evidence

What the research actually shows

We link to relevant studies and leave interpretation to you and your healthcare professional.

Evidence analytics

Where the evidence is concentrated

Number of audited published findings for Coenzyme Q10 by condition. Drill into a pair page for the full breakdown.

Putative uses

Where people report using it and what trials suggest

Moderate evidenceChronic heart failure adjunct (e.g. Q-SYMBIO)
Moderate evidenceMigraine prophylaxis
Moderate evidenceFertility (sperm/egg quality, small trials)

Where the evidence is negative

Common claims the trials do not support

Statins do not cause CoQ10-reversible muscle pain in controlled trials — supplementation doesn't fix statin myalgia.
No benefit for Parkinson's disease progression (large trial null).

Mitochondrial coenzyme with strongest signals in heart-failure adjunct and migraine prevention; famous for its null statin-myalgia trials.

Safety notes: Well tolerated; may reduce warfarin effect; insomnia if dosed late.

Evidence grades reflect study quality and consistency, not marketing claims.

19studies referenced

13journals

2012–2025publication range

01Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025PMID 39940333 ↗02Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High-Intensity Interval Training in Older AdultsBagheri N, et al. · Nutrients · 2025PMID 41470903 ↗03Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized TrialRosselló Aubach L, et al. · Journal of dietary supplements · 2025PMID 40151031 ↗04Interventions for the management of long covid (post-covid condition): living systematic reviewZeraatkar D, et al. · BMJ (Clinical research ed.) · 2024PMID 39603702 ↗05Coenzyme Q10 supplementation in rheumatic diseases: A systematic reviewFreire de Carvalho J, et al. · Clinical nutrition ESPEN · 2024PMID 38220408 ↗06Selenoprotein P increases upon selenium and coenzyme Q(10) supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality

Search PubMed ↗Find clinical trials ↗

What trials found, in numbers

Summaries of published trial results for this compound, grouped by condition. Numbers are reported exactly as the researchers published them — we never calculate or convert.

How to read this table

Benefit: What the trial saw happen: whether the measured outcome moved in the helpful direction in that one study (the tag on each row: “Benefit seen”, “No clear benefit” or “Unclear”). It is a study result — not advice, and not a promise it will work for you.
Evidence: How strong the research behind that result is. A meta-analysis pools many studies (strongest); a systematic review collates them; an RCT tests against a control (placebo); observational studies only watch — they can suggest, not prove.
Effect size: How large the measured change was, exactly as the researchers published it. “No number reported” means the abstract gave no effect size — we never invent one.

In short: benefit is what was observed; evidence is how much you should trust the observation. A “Benefit seen” tag on a weak study counts for far less than the same tag on a meta-analysis.

Fatigue (11 outcomes)

Outcome measured	What trials found	Effect size	People studied	Duration	Type of evidence	Study
anaerobic performance	Anaerobic performance increased with CoQ10 supplementation compared to baseline in athletes.Benefit seen	no number reported	—	—	Systematic review · 2023	PMID 37764774
antioxidant activity	Antioxidant activity increased with CoQ10 supplementation compared to baseline in athletes.Benefit seen	no number reported	—	—	Systematic review · 2023	PMID 37764774
fatigue indicators (Creatine Kinase)	Fatigue indicators decreased with CoQ10 supplementation compared to baseline in athletes.

Outcomes & conditions

Why people look into Coenzyme Q10 — and what they report

Associated conditions and community-reported outcomes, wrapped together on one page. Aggregates appear only once enough reports arrive.

Outcomes & conditions →

Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.

Availability

Where to get Coenzyme Q10 (UK)

How this compound is sold in the UK, and where our readers typically find it.

Retailer search links — we may earn commission on purchases at no cost to you. Commission never affects our evidence ratings.

Search Coenzyme Q10 on Amazon UK →Search Coenzyme Q10 on Holland & Barrett →Search Coenzyme Q10 on iHerb →

Outcome measured	What trials found	Effect size	People studied	Duration	Type of evidence	Study
adverse events	Results for adverse events risk were inconclusive with RR 0.70 vs control in 568 participants. (95% CI 0.45 to 1.10)Unclear	0.70 RR	568	—	Meta-analysis · 2021	PMID 35608922
all-cause mortality	Coenzyme Q10 probably reduced all-cause mortality risk by RR 0.58 vs control in 420 participants. (95% CI 0.35 to 0.95)Benefit seen	0.58 RR	420	—	Meta-analysis · 2021	PMID 35608922
exercise capacity	Results for exercise capacity were inconclusive with MD 48.23 vs control in 91 participants. (95% CI -24.75 to 121.20)Unclear	48.23 MD	91	—	Meta-analysis · 2021	PMID 35608922
hospitalisation related to heart failure	Coenzyme Q10 probably reduced heart failure hospitalisation risk by RR 0.62 vs control in 1061 participants. (95% CI 0.49 to 0.78)Benefit seen	0.62 RR	1061	—	Meta-analysis · 2021	PMID 35608922
left ventricular ejection fraction	Coenzyme Q10 may improve left ventricular ejection fraction by MD 1.77 vs control in 650 participants. (95% CI 0.09 to 3.44)Benefit seen	1.77 MD	650	—	Meta-analysis · 2021	PMID 35608922
myocardial infarction	Results for myocardial infarction risk were inconclusive with RR 1.62 vs control in 420 participants. (95% CI 0.27 to 9.59)Unclear	1.62 RR	420	—	Meta-analysis · 2021	PMID 35608922
stroke	Results for stroke risk were inconclusive with RR 0.18 vs control in 420 participants. (95% CI 0.02 to 1.48)Unclear	0.18 RR	420	—	Meta-analysis · 2021	PMID 35608922