Coenzyme Q10 for Fatigue
Fat-soluble compound essential to mitochondrial ATP production and antioxidant defence; levels decline with age and statin use, so supplementation is studied for statin-associated muscle symptoms and cardiovascular support.
Coenzyme Q10 for Fatigue
6 of 6 results reported a benefit, from 2 published studies.
2 studies, including a review of trials · the chart counts everything measured
- 6 reported a benefit
Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.
- Fatigue symptomsSlight effectslightly better than the comparison group1 review of trials2022 study ↗
Also measured in these studies (1)
These were measured alongside, but they are not what this condition is about.
- Short-burst exercise performanceReported a benefitmeasurement not reportedAnaerobic performance increased with CoQ10 supplementation compared to baseline in athletes.1 review of trials2023 study ↗
4 laboratory markers also measured
- Antioxidant activity · lab markerReported a benefitmeasurement not reportedAntioxidant activity increased with CoQ10 supplementation compared to baseline in athletes.1 review of trials2023 study ↗
- Liver enzymes · lab markerReported a benefitmeasurement not reportedLiver damage markers decreased with CoQ10 supplementation compared to baseline in athletes.1 review of trials2023 study ↗
- Muscle damage marker (creatine kinase) · lab markerReported a benefitmeasurement not reportedFatigue indicators decreased with CoQ10 supplementation compared to baseline in athletes.1 review of trials2023 study ↗
- Oxidative stress markers · lab markerReported a benefitmeasurement not reportedOxidative stress markers decreased with CoQ10 supplementation compared to baseline in athletes.1 review of trials2023 study ↗
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every result is listed below.
See every resultThe connection
Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.
Also known as: CoQ10, Ubiquinone, Ubiquinol
Coenzyme Q10 × Fatigue: at a glance
Every published result for this pair, extracted and audited.
These charts count reported findings from published studies, grouped by reported benefit and study design. Study design is not a certainty grade.
Coenzyme Q10 / Fatigue: reported findings; one study may contribute several findings.
What the evidence shows
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Benefit | 6 |
Study designs behind these findings
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Systematic review | 6 |
- Studies
- 2
| Study | Outcome | Reported result | Uncertainty (as reported) | Study duration |
|---|---|---|---|---|
| Coenzyme Q10 Supplementation in Athletes: A Systematic Review. (PMID 37764774) | anaerobic performance | Not reported | Not reported | Not reported |
| Coenzyme Q10 Supplementation in Athletes: A Systematic Review. (PMID 37764774) | antioxidant activity | Not reported | Not reported | Not reported |
| Coenzyme Q10 Supplementation in Athletes: A Systematic Review. (PMID 37764774) | fatigue indicators (Creatine Kinase) | Not reported | Not reported | Not reported |
| Coenzyme Q10 Supplementation in Athletes: A Systematic Review. (PMID 37764774) | liver damage markers (ALT, AST, γGT) | Not reported | Not reported | Not reported |
| Coenzyme Q10 Supplementation in Athletes: A Systematic Review. (PMID 37764774) | oxidative stress markers | Not reported | Not reported | Not reported |
| Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PMID 36091835) | fatigue scores | -0.398 Hedges' g | 95% confidence interval = -0.641 to -0.155, p = 0.001 | Not reported |
Study results, as reported by the publications
Every measured outcome, one row per finding - numbers exactly as reported. Units are preserved where supplied; missing units are not inferred.
| Study and type | Reported sample and duration | Outcome measured | Reported result | What studies found |
|---|---|---|---|---|
| PMID 37764774 2023 Systematic review | Sample (as reported): Not reportedDuration: Not reported | anaerobic performance | Not reported | Benefit |
| PMID 37764774 2023 Systematic review | Sample (as reported): Not reportedDuration: Not reported | antioxidant activity | Not reported | Benefit |
| PMID 37764774 2023 Systematic review | Sample (as reported): Not reportedDuration: Not reported | fatigue indicators (Creatine Kinase) | Not reported | Benefit |
| PMID 37764774 2023 Systematic review | Sample (as reported): Not reportedDuration: Not reported | liver damage markers (ALT, AST, γGT) | Not reported | Benefit |
| PMID 37764774 2023 Systematic review | Sample (as reported): Not reportedDuration: Not reported | oxidative stress markers | Not reported | Benefit |
| PMID 36091835 2022 Systematic review | Sample (as reported): 1,126Duration: Not reported | fatigue scores | -0.398 Hedges' g (95% confidence interval = -0.641 to -0.155, p = 0.001) | Benefit |
Coenzyme Q10 × Fatigue: the evidence base
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-AnalysisIsmail O, et al. · Musculoskeletal care · 2025PMID 39832803 ↗02Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025PMID 39940333 ↗03Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025PMID 40797337 ↗04Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic reviewFiani D, et al. · Neuroscience and biobehavioral reviews · 2025PMID 40945632 ↗05Coenzyme Q10 supplementation in rheumatic diseases: A systematic reviewFreire de Carvalho J, et al. · Clinical nutrition ESPEN · 2024PMID 38220408 ↗06A Systematic Review of Symptoms of Pernicious AnemiaSeage CH, et al. · Food and nutrition bulletin · 2024PMID 38987871 ↗Community experiences
Contributors volunteered; this does not establish treatment effectiveness or population incidence.
Reported changes
No publishable community breakdown is available. This does not establish that no reports exist.