General Health

Fatigue

About Fatigue — General Health.

Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.

6studies analysed

3compounds with evidence

Systematic reviewstrongest evidence

Where research is strongest

Add your outcome — free & pseudonymous

Tried something for Fatigue? Share how it went — only ever published as part of a group of 10+.

4linked compounds

60linked studies

0published community reports

Results By the numbers Community Research Compounds

Headline results for Fatigue.

Figures as the studies reported them.

Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.

Coq10

6 of 6 results reported a benefit

2 studies, including a review of trials

Fatigue symptomsSlight effectslightly better than the comparison group1 review of trials2022 study ↗

Also measured alongside: Short-burst exercise performance (reported a benefit); Antioxidant activity (reported a benefit); Liver enzymes (reported a benefit); and 2 more.

Every result

Rhodiola Rosea

4 of 7 results reported a benefit

3 randomised trials, 60 people

Fatigue symptoms1.9higher, unit not reported on the VAS-F scale1 randomised trial2014 study ↗
Energy and vitality17.3lower, unit not reported on the RAND-36 scale1 randomised trial2014 study ↗

No figure given: Burnout symptoms (reported a benefit); Mental performance when tired (reported a benefit).

Also measured alongside: Attention test scores (reported a benefit); Mental health and depression (no clear benefit); Morning cortisol (stress hormone) response (reported a benefit).

Every result

Vitamin D3

2 of 2 results reported a benefit

1 randomised trial, 120 people

Fatigue symptomsFell by 3.3 vs 0.8in the comparison group, unit not reported on the FAS scale1 randomised trial2016 study ↗
People reporting less fatigue2.63 timesthe odds of the comparison group1 randomised trial2016 study ↗

Every result

Where the evidence is concentrated.

Published research

Fatigue: findings by compound

What this means: Bars count reported findings, not treatment effectiveness or certainty.

One study may report several findings or appear in more than one pairing. Counts do not show the size of an effect. Comparable numerical estimates are not established for this summary.

View the full data table

Published research: reported directions by pairing
Compound and condition	Findings (count)	Studies (count)	Reported results (finding counts)	How sure?
Coq10	6	2	Benefit: 6; no benefit: 0; harm: 0; unclear: 0; not recorded / unrecognised: 0	Not formally graded
Rhodiola Rosea	8	3	Benefit: 4; no benefit: 2; harm: 2; unclear: 0; not recorded / unrecognised: 0	Not formally graded
Vitamin D3	2	1	Benefit: 2; no benefit: 0; harm: 0; unclear: 0; not recorded / unrecognised: 0	Not formally graded

Degree of benefit for Fatigue

Strongest evidence first.

Published research: Fatigue. Study design is not a certainty grade.
Compound	Study designs	Reported findings
Coq10Research score 67/100 · Moderate	2 systematic reviews/meta-analyses — 2 studies	6/6 outcomes showed benefit Fatigue scoresSlightly better than the comparison group (slight effect)benefit2022 study ↗ Exact figures -0.398 (95% confidence interval = -0.641 to -0.155, p = 0.001) n=1,126 · Follow-up: Not reported · Sample (as reported): 1,126 · Recorded unit: Not reported · Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. · Systematic Review · systematic-review · PMID 36091835 Fatigue indicators (Creatine Kinase) — a marker of muscle damageReported a benefit — measurement not reportedbenefit2023 study ↗ Exact figures No figures reported · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · Coenzyme Q10 Supplementation in Athletes: A Systematic Review. · Systematic Review · systematic-review · PMID 37764774 Anaerobic performanceReported a benefit — measurement not reportedbenefit2023 study ↗ Exact figures No figures reported · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · Coenzyme Q10 Supplementation in Athletes: A Systematic Review. · Systematic Review · systematic-review · PMID 37764774 Antioxidant activityReported a benefit — measurement not reportedbenefit2023 study ↗ Exact figures No figures reported · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · Coenzyme Q10 Supplementation in Athletes: A Systematic Review. · Systematic Review · systematic-review · PMID 37764774 +2 more outcomes →
Rhodiola RoseaResearch score 41/100 · Limited	3 randomised trials — 3 studies	4/8 outcomes showed benefit Burnout symptoms (Pines' burnout scale)Reported a benefit — measurement not reportedbenefit2009 study ↗ Exact figures n=60 · Follow-up: 28 days · Sample (as reported): 60 · Recorded unit: Not reported · A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. · Randomized Controlled Trial · rct · PMID 19016404 Mental performance / Fatigue Index tests after night dutyReported a benefit — measurement not reportedbenefit2000 study ↗ Exact figures n=56 · Follow-up: two weeks · Sample (as reported): 56 · Recorded unit: Not reported · Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. · Randomized Controlled Trial · rct · PMID 11081987 Fatigue (VAS-F) at day 42 — a 0-100 rating scale1.9 higher, unit not reportedpossible harm2014 study ↗ Exact figures 1.9 (95% CI 0.4, 3.5; p = 0.015) n=48 · Follow-up: day 42 · Sample (as reported): 48 · Recorded unit: Not reported · Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial. · Randomized Controlled Trial · rct · PMID 25268730 Attention (CCPT II indices: omissions, Hit RT SE, variability)Reported a benefit — measurement not reportedbenefit2009 study ↗ Exact figures n=60 · Follow-up: 28 days · Sample (as reported): 60 · Recorded unit: Not reported · A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. · Randomized Controlled Trial · rct · PMID 19016404 +4 more outcomes →
Vitamin D3Research score 44/100 · Limited	1 randomised trial — 1 study	2/2 outcomes showed benefit Amelioration of fatigue2.63 times the odds of the comparison groupbenefit2016 study ↗ Exact figures 2.63; 50% (P=0.01; odds ratio [OR] 2.63, 95% CI for OR 1.23-5.62) n=120 · Follow-up: 4 weeks · Sample (as reported): 120 · Recorded unit: Not reported · Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial. · Randomized Controlled Trial · rct · PMID 28033244 Intra-individual change in the fatigue assessment scale (FAS) — a fatigue questionnaireFell by 3.3 vs 0.8 in the comparison group, unit not reportedbenefit2016 study ↗ Exact figures -3.3; -0.8 (95% confidence interval [CI] for change -14.1 to 4.1; P=0.01) n=120 · Follow-up: 4 weeks · Sample (as reported): 120 · Recorded unit: Not reported · Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial. · Randomized Controlled Trial · rct · PMID 28033244

Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.

No community reports published yet.

We publish fatigue results only once at least 10 people report on the same compound, so no individual report is ever shown.

Coq10
Research saysResearch score 67/100 · Moderate2 of 2 studies reported at least one benefit
People reportNot published yet — needs 10 or more reports
Vitamin D3
Research saysResearch score 44/100 · Limited1 of 1 study reported at least one benefit
People reportNot published yet — needs 10 or more reports
Rhodiola Rosea
Research saysResearch score 41/100 · Limited2 of 3 studies reported at least one benefit
People reportNot published yet — needs 10 or more reports

Used something for fatigue? Share how it went — only ever published in a group of 10 or more.

Add your outcome

Peer-reviewed research.

Every study behind the numbers above is linked next to its result.

54 more papers, not summarised above

Strongest evidence first.

01Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-AnalysisIsmail O, et al. · Musculoskeletal care · 2025

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 39832803 ↗02Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 39940333 ↗03Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025

Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)

PMID 40797337 ↗04Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic reviewFiani D, et al. · Neuroscience and biobehavioral reviews · 2025

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 40945632 ↗05Coenzyme Q10 supplementation in rheumatic diseases: A systematic reviewFreire de Carvalho J, et al. · Clinical nutrition ESPEN · 2024

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 38220408 ↗06A Systematic Review of Symptoms of Pernicious AnemiaSeage CH, et al. · Food and nutrition bulletin · 2024

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 38987871 ↗07A systematic review on sustainable utilization of plastic waste in asphalt: assessing environmental and health impact, performance, and economic viabilityMohammadi R, et al. · Environmental science and pollution research international · 2024

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 39487917 ↗08Interventions for the management of long covid (post-covid condition): living systematic reviewZeraatkar D, et al. · BMJ (Clinical research ed.) · 2024

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 39603702 ↗09Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-AnalysisLópez-Muñoz P, et al. · Nutrients · 2023

Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)

PMID 37447189 ↗10Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-RegressionMarkun S, et al. · Nutrients · 2021

Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)

PMID 33809274 ↗11Plant Adaptogens-History and Future PerspectivesTodorova V, et al. · Nutrients · 2021

Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)

PMID 34445021 ↗12Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence SynthesisLowry E, et al. · Nutrients · 2020

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 32878326 ↗13Efficacy and Safety of Vitamin D Supplementation in Patients With Systemic Lupus Erythematosus: A Meta-analysis of Randomized Controlled TrialsZheng R, et al. · The American journal of the medical sciences · 2019

Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)

PMID 31331447 ↗14Integrative Therapies for Cancer-Related FatigueArring NM, et al. · Cancer journal (Sudbury, Mass.) · 2019

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 31567463 ↗15Vitamin D for the management of multiple sclerosisJagannath VA, et al. · The Cochrane database of systematic reviews · 2018

Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)

PMID 30246874 ↗16Daily iron supplementation for improving anaemia, iron status and health in menstruating womenLow MS, et al. · The Cochrane database of systematic reviews · 2016

Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)

PMID 27087396 ↗17Rhodiola rosea for physical and mental fatigue: a systematic reviewIshaque S, et al. · BMC complementary and alternative medicine · 2012

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 22643043 ↗18The effect of vitamin B6 on cognitionMalouf R, et al. · The Cochrane database of systematic reviews · 2003

Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)

PMID 14584010 ↗19Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical studyMcKinney E, et al. · Trials · 2026