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Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Coq10 | 2 systematic review/meta-analysis outcomes | Anaerobic performance increased with CoQ10 supplementation compared to baseline in athletes.11/3 outcomes showed benefit | PMID 37764774 |
| Iron | 1 systematic review/meta-analysis outcome | Iron supplementation showed no significant difference in maximal oxygen consumption compared to placebo or active therapy in 235 participants.3/1 outcomes showed benefit | PMID 29626044 |
| Rhodiola Rosea | 3 randomised trial outcomes | Total adverse events did not differ significantly between Rhodiola rosea and placebo groups by day 42.4/3 outcomes showed benefit | PMID 25268730 |
| Shilajit | 1 randomised trial outcome | High dose Shilajit reduced strength decline to 8.9% vs placebo at 16.0% in 21 men over 8 weeks.2/1 outcomes showed benefit | PMID 30728074 |
| Vitamin D3 | 1 randomised trial outcome | Fatigue amelioration occurred in 72% vs 50% placebo in 120 people over 4 weeks.2/1 outcomes showed benefit | PMID 28033244 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Randomized Controlled Trial · matched via Fatigue · PubMed record (CORPUS-A)
PMID 41656269 ↗02Effects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel diseaseRamezani E, et al. · Scientific reports · 2026Randomized Controlled Trial · matched via Fatigue · PubMed record (CORPUS-A)
PMID 42010310 ↗03Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)
PMID 40797337 ↗04The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trialAlmassri HF, et al. · Clinical nutrition ESPEN · 2025Randomized Controlled Trial · matched via Fatigue · PubMed record (CORPUS-A)
PMID 39577691 ↗05The effect of vitamin D supplementation on mental and functional health outcomes in African Americans with type 2 diabetesJones KE, et al. · The Journal of steroid biochemistry and molecular biology · 2025Randomized Controlled Trial · matched via Fatigue · PubMed record (CORPUS-A)
PMID 39952368 ↗Randomized Controlled Trial · matched via Fatigue · open-access full text · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Significantly reduced over 12 weeks
Adults with burnout · Randomised controlled trial · PMID 19649319 ↗Moderate evidenceReduced02Fatigue — ImprovedSymptoms improved after correcting deficiency
Vitamin-D-deficient primary-care patients · Cross-sectional study · PMID 23760026 ↗Weak evidenceImproved03Mental fatigue — ReducedReduced; cognitive performance improved (5g daily)
Vegetarians · Randomised controlled trial · PMID 23416054 ↗Moderate evidenceReducedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.