Loading…
Chronic systemic inflammation underlies most modern diseases — heart disease, diabetes, autoimmune conditions.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Black Seed OIL | 6 systematic review/meta-analysis outcomes | GPx levels significantly improved by SMD 1.23 in 1086 participants compared to control.29/6 outcomes showed benefit | PMID 37036558 |
| Green TEA Extract | 1 systematic review/meta-analysis outcome | Green tea catechins showed no significant effect on plasma CRP vs control in 11 RCT arms.0/1 outcomes showed benefit | PMID 26233863 |
| Omega 3 | 1 systematic review/meta-analysis outcome | Omega-3 supplementation reduced IL-6 levels by an effect size of -0.22 compared to control in adults.3/1 outcomes showed benefit | PMID 35914448 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
Be the first to share what has helped with inflammation.
Open the original papers, check their methods, and discuss what is relevant with a qualified professional.
Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)
PMID 41568426 ↗02Effects of Green Tea Extract Supplementation on Inflammatory Cytokines Among Postmenopausal Women with Overweight or Obesity-A Secondary Analysis of a Randomized Controlled TrialCunningham A, et al. · Nutrients · 2026Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)
PMID 41515260 ↗03Maternal Adiposity and Inflammation: Risk Factors for Iron Deficiency in PregnancyDemirdjian SP, et al. · The Journal of nutrition · 2025Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)
PMID 40886951 ↗04Using the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNAMcFarlin BK, et al. · Nutrients · 2025Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)
PMID 40507030 ↗05Agrarian diet improves metabolic health in HIV-positive men with Prevotella-rich microbiomes: results from a randomized trialO'Connor JB, et al. · mSystems · 2025Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)
PMID 41294355 ↗Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Significantly reduced across 15 trials
Adults in supplementation trials · Meta-analysis · PMID 30851863 ↗Strong evidenceReduced02Inflammatory eicosanoids and cytokines — ReducedReduced production (EPA and DHA)
Adults · Systematic review · PMID 29065491 ↗Strong evidenceReducedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.