Community observations, not medical advice.Always speak with a qualified healthcare professional.
General Health

Inflammation

About Inflammation — General Health.

Chronic systemic inflammation underlies most modern diseases — heart disease, diabetes, autoimmune conditions.

7studies analysed
3compounds with evidence
Systematic reviewstrongest evidence
Add your outcome — free & pseudonymous

Tried something for Inflammation? Share how it went — only ever published as part of a group of 10+.

5linked compounds
52linked studies
0published community reports

Headline results for Inflammation.

Figures as the studies reported them.

Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.

23of 30

Black Seed OIL

23 of 30 results reported a benefit

5 studies, including a review of trials

  • Inflammation marker (CRP)No clear difference0.98 mg/L lower1 review of trials2 of 4 results reported a benefit2021 study ↗
  • Inflammation marker (TNF-alpha)2.15 pg/mLlower1 review of trials3 of 4 results reported a benefit2021 study ↗
  • Inflammation marker (IL-6)No clear difference0.25 pg/mL lower1 review of trials1 of 2 results reported a benefit2021 study ↗

Also measured alongside: 'Bad' (LDL) cholesterol (reported a benefit); Fasting blood sugar (reported a benefit); Long-term blood sugar (HbA1c) (reported a benefit); and 7 more.

Every result
3of 3

Omega 3

3 of 3 results reported a benefit

1 review of trials

  • Inflammation marker (CRP)Slight effectslightly better than the comparison group1 review of trials2022 study ↗
  • Inflammation marker (IL-6)Slight effectslightly better than the comparison group1 review of trials2022 study ↗
  • Inflammation marker (TNF-alpha)Slight effectslightly better than the comparison group1 review of trials2022 study ↗
Every result

Where the evidence is concentrated.

Published research

Inflammation: findings by compound

What this means: Bars count reported findings, not treatment effectiveness or certainty.

One study may report several findings or appear in more than one pairing. Counts do not show the size of an effect. Comparable numerical estimates are not established for this summary.

View the full data table
Published research: reported directions by pairing
Compound and conditionFindings (count)Studies (count)Reported results (finding counts)How sure?
Black Seed OIL305Benefit: 23; no benefit: 7; harm: 0; unclear: 0; not recorded / unrecognised: 0Not formally graded
Green TEA Extract11Benefit: 0; no benefit: 1; harm: 0; unclear: 0; not recorded / unrecognised: 0Not formally graded
Omega 331Benefit: 3; no benefit: 0; harm: 0; unclear: 0; not recorded / unrecognised: 0Not formally graded

Degree of benefit for Inflammation

Strongest evidence first.

Published research: Inflammation. Study design is not a certainty grade.
CompoundStudy designsReported findings
Black Seed OILResearch score 68/100 · Moderate5 systematic reviews/meta-analyses — 5 studies23/30 outcomes showed benefit
  • High-sensitivity C-reactive protein (hs-CRP) — a blood marker of inflammation0.67 lower, unit not reportedbenefit2021 study ↗
    Exact figures-0.67 (95% CI: -1.29, -0.05) · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. · Meta-Analysis · meta-analysis · PMID 33559935
  • Malondialdehyde (MDA) — a marker of oxidative cell damage1.18 lower, unit not reportedbenefit2021 study ↗
    Exact figures-1.18 (95% CI: -2.24, -0.12) · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. · Meta-Analysis · meta-analysis · PMID 33559935
  • Superoxide dismutase (SOD) — an antioxidant enzyme the body makes66.3 higher, unit not reportedbenefit2021 study ↗
    Exact figures66.30 (95% CI: 1.03, 131.57) · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. · Meta-Analysis · meta-analysis · PMID 33559935
  • Total antioxidant capacity (TAC) — overall antioxidant level in the blood0.35 higher, unit not reportedbenefit2021 study ↗
    Exact figures0.35 (95% CI: 0.10, 0.59) · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. · Meta-Analysis · meta-analysis · PMID 33559935
+26 more outcomes →
Green TEA ExtractResearch score 0/100 · Mixed/Weak1 systematic review/meta-analysis — 1 study0/1 outcomes showed benefit
  • Plasma C-reactive protein concentrations — a blood marker of inflammationNo clear difference (0.09 mg/L higher)no benefit2015 study ↗
    Exact figures0.085 mg/L (95% CI, -0.225 to 0.395; P = 0.592) n=11 RCTs arms · Follow-up: <8 wk and ≥8 wk · Sample (as reported): 11 RCTs arms · Recorded unit: mg/L · Effects of supplementation with green tea catechins on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials. · Meta-Analysis · meta-analysis · PMID 26233863
Omega 3Research score 50/100 · Moderate1 systematic review/meta-analysis — 1 study3/3 outcomes showed benefit
  • Interleukin 6 (IL-6) — a signal that drives inflammationSlightly better than the comparison group (slight effect)benefit2022 study ↗
    Exact figures-0.22 (95% CI: -0.39, -0.05, p=0.010) · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. · Meta-Analysis · meta-analysis · PMID 35914448
  • Serum C-reactive protein (CRP) — a blood marker of inflammationSlightly better than the comparison group (slight effect)benefit2022 study ↗
    Exact figures-0.40 (95% CI: -0.56, -0.24, p<0.001) · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. · Meta-Analysis · meta-analysis · PMID 35914448
  • Tumour necrosis factor α (TNFα) — a signal that drives inflammationSlightly better than the comparison group (slight effect)benefit2022 study ↗
    Exact figures-0.23 (95% CI: -0.37, -0.08, p=0.002) · Follow-up: Not reported · Sample (as reported): Not reported · Recorded unit: Not reported · Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. · Meta-Analysis · meta-analysis · PMID 35914448
Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.

No community reports published yet.

We publish inflammation results only once at least 10 people report on the same compound, so no individual report is ever shown.

  • Black Seed OIL

    Research saysResearch score 68/100 · Moderate5 of 5 studies reported at least one benefit
    People reportNot published yet — needs 10 or more reports
  • Omega 3

    Research saysResearch score 50/100 · Moderate1 of 1 study reported at least one benefit
    People reportNot published yet — needs 10 or more reports
  • Green TEA Extract

    Research saysResearch score 0/100 · Mixed/Weak0 of 1 study reported at least one benefit
    People reportNot published yet — needs 10 or more reports

Used something for inflammation? Share how it went — only ever published in a group of 10 or more.

Add your outcome

Peer-reviewed research.

Every study behind the numbers above is linked next to its result.

45 more papers, not summarised above

Strongest evidence first.

01Role of the EPA: DHA dosing ratio in omega-3 supplements on blood fatty acid profiles and inflammation: a systematic review and meta-analysisKhabir Z, et al. · Critical reviews in food science and nutrition · 2026

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 41568426 ↗
02Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic ReviewMalcangi G, et al. · Nutrients · 2025

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 40077632 ↗
03Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysisGhobadi H, et al. · Inflammopharmacology · 2025

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 40839182 ↗
04The effect of two anti-inflammatory dietary components, omega-3 and resveratrol, on endometriosisSienko A, et al. · Ginekologia polska · 2024

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 37768015 ↗
05The Antiobesity Effects and Potential Mechanisms of TheaflavinsFang Y, et al. · Journal of medicinal food · 2024

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 38060708 ↗
06Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trialsWang W, et al. · Clinical rheumatology · 2024

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 38922552 ↗
07Omega-3 Fatty Acid Supplementation on Post-Exercise Inflammation, Muscle Damage, Oxidative Response, and Sports Performance in Physically Healthy Adults-A Systematic Review of Randomized Controlled TrialsFernández-Lázaro D, et al. · Nutrients · 2024

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 38999792 ↗
08Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the EvidenceNunes YC, et al. · Nutrients · 2024

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 39203857 ↗
09Evaluation of curcumin intake in reducing exercise-induced muscle damage in athletes: a systematic reviewDaniel Vasile PR, et al. · Journal of the International Society of Sports Nutrition · 2024

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 39623590 ↗
10Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic ReviewRanneh Y, et al. · Nutrients · 2024

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 39683546 ↗
11Curcumin Attenuates Hyperglycemia and Inflammation in Type 2 Diabetes Mellitus: Quantitative Analysis of Randomized Controlled TrialMokgalaboni K, et al. · Nutrients · 2024

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 39683570 ↗
12Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trialsDehzad MJ, et al. · Cytokine · 2023

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 36804260 ↗
13Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trialsLong Z, et al. · Frontiers in immunology · 2023

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 37033930 ↗
14A large meta-analysis identifies genes associated with anterior uveitisGelfman S, et al. · Nature communications · 2023

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 37949852 ↗
15Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic reviewHipólito-Reis M, et al. · Phytotherapy research : PTR · 2022

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 35583746 ↗
16Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled TrialZeng L, et al. · Frontiers in immunology · 2022

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 35935936 ↗
17Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to InterventionJiao H, et al. · International journal of environmental research and public health · 2022

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 36231195 ↗
18Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic reviewAlAmmar WA, et al. · Nutritional neuroscience · 2021

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 31462182 ↗
19The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo StudiesHenshaw FR, et al. · Cannabis and cannabinoid research · 2021

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 33998900 ↗
20Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus: A reviewMohebbati R, et al. · Journal of ethnopharmacology · 2020

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 31972323 ↗
21Biological effects of Cannabidiol on normal human healthy cell populations: Systematic review of the literaturePagano S, et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 33038581 ↗
22Effect of Nigella sativa L. supplementation on inflammatory and oxidative stress indicators: A systematic review and meta-analysis of controlled clinical trialsMohit M, et al. · Complementary therapies in medicine · 2020

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 33183658 ↗
23The Use of Cannabinoids in Colitis: A Systematic Review and Meta-AnalysisCouch DG, et al. · Inflammatory bowel diseases · 2018

Meta-Analysis · matched via Inflammation · PubMed record (CORPUS-A)

PMID 29562280 ↗
24A review on phytochemical and pharmacological properties of Litsea coreanaJia X, et al. · Pharmaceutical biology · 2017

Systematic Review · matched via Inflammation · PubMed record (CORPUS-A)

PMID 28301985 ↗
25Effects of Green Tea Extract Supplementation on Inflammatory Cytokines Among Postmenopausal Women with Overweight or Obesity-A Secondary Analysis of a Randomized Controlled TrialCunningham A, et al. · Nutrients · 2026

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 41515260 ↗
26Using the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNAMcFarlin BK, et al. · Nutrients · 2025

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 40507030 ↗
27Anti-Inflammatory, Antithrombotic and Antioxidant Efficacy and Synergy of a High-Dose Vitamin C Supplement Enriched with a Low Dose of Bioflavonoids; In Vitro Assessment and In Vivo Evaluation Through a Clinical Study in Healthy SubjectsChrysikopoulou V, et al. · Nutrients · 2025

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 40871671 ↗
28Maternal Adiposity and Inflammation: Risk Factors for Iron Deficiency in PregnancyDemirdjian SP, et al. · The Journal of nutrition · 2025

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 40886951 ↗
29Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trialLi S, et al. · Age and ageing · 2025

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 40966617 ↗
30Agrarian diet improves metabolic health in HIV-positive men with Prevotella-rich microbiomes: results from a randomized trialO'Connor JB, et al. · mSystems · 2025

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 41294355 ↗
31A crossover randomized controlled trial examining the effects of black seed (Nigella sativa) supplementation on IL-1β, IL-6 and leptin, and insulin parameters in overweight and obese womenRazmpoosh E, et al. · BMC complementary medicine and therapies · 2024

Randomized Controlled Trial · matched via Inflammation · open-access full text · PubMed record (CORPUS-A)

PMID 38178093 ↗
32A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndromeZeng M, et al. · Nutrition research (New York, N.Y.) · 2024

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 38430822 ↗
33Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical TrialErol Doğan Ö, et al. · Nutrients · 2024

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 38794742 ↗
34Effect of Omega-3 Polyunsaturated Fatty Acid Supplementation on Clinical Outcome of Atopic Dermatitis in ChildrenNiseteo T, et al. · Nutrients · 2024

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 39275147 ↗
35Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trialFrançois B, et al. · The Lancet. Respiratory medicine · 2023

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 37269870 ↗
36The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled TrialMiller L, et al. · Nutrients · 2021

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 34684621 ↗
37Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of ANDROMEDAPalladini G, et al. · Blood · 2020

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 32244252 ↗
38Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trialJung SJ, et al. · BMC complementary and alternative medicine · 2019

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 30925876 ↗
39Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trialWithee ED, et al. · Journal of the International Society of Sports Nutrition · 2017

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 28736511 ↗
40Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trialNotarnicola A, et al. · International journal of immunopathology and pharmacology · 2016

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 26684635 ↗
41Growth differentiation factor 15, a marker of oxidative stress and inflammation, for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trialWallentin L, et al. · Circulation · 2014

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 25294786 ↗
42A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trialNieman DC, et al. · Nutrition journal · 2013

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 24274358 ↗
43A comparison of the short-term effects of oral conjugated equine estrogens versus transdermal estradiol on C-reactive protein, other serum markers of inflammation, and other hepatic proteins in naturally menopausal womenShifren JL, et al. · The Journal of clinical endocrinology and metabolism · 2008

Randomized Controlled Trial · matched via Inflammation · PubMed record (CORPUS-A)

PMID 18303079 ↗
44Omega-3 and chronic inflammation: A systematic reviewCalder PC et al. · Biochem Soc Trans · 2023

EPA and DHA reduce production of inflammatory eicosanoids and cytokines.

PMID 29065491 ↗
45Curcumin reduces inflammatory markers: A meta-analysisSahebkar A et al. · Clin Nutr · 2023

Curcumin supplementation significantly reduced CRP and inflammatory cytokines across 15 trials.

PMID 30851863 ↗
Important: Studies vary in quality and relevance. We do not interpret them or give medical advice.