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Frequent illness, weak immune response, slow recovery from infections.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Vitamin C | 1 systematic review/meta-analysis outcome | Vitamin C significantly shortened infection duration compared to placebo (SMD -0.36, P=0.01).1/1 outcomes showed benefit | PMID 34967304 |
| Probiotics | 1 randomised trial outcome | Galectin-1 was upregulated in Th2 and Th17 cells in infants supplemented with Bifidobacterium infantis EVC001 compared to those lacking bifidobacteria.3/1 outcomes showed benefit | PMID 34143954 |
| Reishi | 1 randomised trial outcome | High-dose Ganoderma showed a nonsignificant trend toward preserving the lymphocyte ratio compared to placebo during altitude training.0/1 outcomes showed benefit | PMID 18048435 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Randomized Controlled Trial · matched via Immune Support · PubMed record (CORPUS-A)
PMID 41507560 ↗02Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026Weiss SL, et al. · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Systematic Review · matched via Immune Support · PubMed record (CORPUS-A)
PMID 41869844 ↗03Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026Weiss SL, et al. · Intensive care medicine · 2026Systematic Review · matched via Immune Support · PubMed record (CORPUS-A)
PMID 41870559 ↗04Clinical benefits and risks of high-dose intravenous vitamin C: a systematic reviewAlangari A, et al. · Journal of medicine and life · 2026Systematic Review · matched via Immune Support · PubMed record (CORPUS-A)
PMID 41815850 ↗05Comparison of adjuvant and neoadjuvant therapies for muscle invasive bladder cancer: A network meta-analysisPetrelli F, et al. · Urologic oncology · 2026Network Meta-Analysis · matched via Immune Support · PubMed record (CORPUS-A)
PMID 40935764 ↗06Systematic Review · matched via Immune Support · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Reduced by ~33% (zinc lozenges ≥75mg/day)
Common-cold patients · Meta-analysis · PMID 24046771 ↗Strong evidenceReduced02Acute respiratory tract infection risk — ReducedReduced, especially in deficient individuals
Supplementing adults · Individual-participant-data meta-analysis · PMID 25849498 ↗Strong evidenceReduced03Pneumonia risk — ReducedReduced by up to 80% in stressed populations
Stressed subgroups · Systematic review · PMID 24584642 ↗Strong evidenceReducedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.