Circadian disruption from rapid travel across time zones. Affects sleep, digestion, and cognition.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Melatonin | 3 systematic review/meta-analysis outcomes | It is unclear if oral melatonin causes adverse effects compared to no treatment in 11 randomized trials, though they would probably be mild.5/4 outcomes showed benefit | PMID 26731279 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
Be the first to share what has helped with jet lag.
Open the original papers, check their methods, and discuss what is relevant with a qualified professional.
Melatonin taken near target bedtime at destination reduced jet lag symptoms across 9 trials.
PMID 11869644 ↗02Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic reviewHester L, et al. · Chronobiology international · 2021Systematic Review · matched via JET LAG · PubMed record (CORPUS-A)
PMID 34030534 ↗03How to manage travel fatigue and jet lag in athletes? A systematic review of interventionsJanse van Rensburg DCC, et al. · British journal of sports medicine · 2020Systematic Review · matched via JET LAG · PubMed record (CORPUS-A)
PMID 32303523 ↗04What works for jetlag? A systematic review of non-pharmacological interventionsBin YS, et al. · Sleep medicine reviews · 2019Systematic Review · matched via JET LAG · PubMed record (CORPUS-A)
PMID 30529430 ↗05Is melatonin useful for jet lag?Tortorolo F, et al. · Medwave · 2015Meta-Analysis · matched via JET LAG · PubMed record (CORPUS-A)
PMID 26731279 ↗06Jet lagHerxheimer A · BMJ clinical evidence · 2014Systematic Review · matched via JET LAG · PubMed record (CORPUS-A)
PMID 24780537 ↗Randomized Controlled Trial · matched via JET LAG · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Figures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.