Omega-3 (EPA/DHA) for Inflammation
Long-chain polyunsaturated fatty acids from fish or algal oil that are incorporated into cell membranes and reduce pro-inflammatory eicosanoid production; linked to cardiovascular, joint, and neurological benefits.
Omega-3 (EPA/DHA) for Inflammation
3 of 3 results reported a benefit, from 1 published study.
1 review of trials · the chart counts everything measured
- 3 reported a benefit
Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.
- Inflammation marker (CRP)Slight effectslightly better than the comparison group1 review of trials2022 study ↗
- Inflammation marker (IL-6)Slight effectslightly better than the comparison group1 review of trials2022 study ↗
- Inflammation marker (TNF-alpha)Slight effectslightly better than the comparison group1 review of trials2022 study ↗
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every result is listed below.
See every resultThe connection
Chronic systemic inflammation underlies most modern diseases — heart disease, diabetes, autoimmune conditions.
Also known as: Fish Oil, Krill Oil, EPA, DHA
Omega-3 (EPA/DHA) × Inflammation: at a glance
Every published result for this pair, extracted and audited.
These charts count reported findings from published studies, grouped by reported benefit and study design. Study design is not a certainty grade.
Omega-3 (EPA/DHA) / Inflammation: reported findings; one study may contribute several findings.
What the evidence shows
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Benefit | 3 |
Study designs behind these findings
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Meta-analysis | 3 |
- Studies
- 1
| Study | Outcome | Reported result | Uncertainty (as reported) | Study duration |
|---|---|---|---|---|
| Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. (PMID 35914448) | interleukin 6 (IL-6) | -0.22 | 95% CI: -0.39, -0.05, p=0.010 | Not reported |
| Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. (PMID 35914448) | serum C-reactive protein (CRP) | -0.40 | 95% CI: -0.56, -0.24, p<0.001 | Not reported |
| Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. (PMID 35914448) | Tumour necrosis factor α (TNFα) | -0.23 | 95% CI: -0.37, -0.08, p=0.002 | Not reported |
Study results, as reported by the publications
Every measured outcome, one row per finding - numbers exactly as reported. Units are preserved where supplied; missing units are not inferred.
| Study and type | Reported sample and duration | Outcome measured | Reported result | What studies found |
|---|---|---|---|---|
| PMID 35914448 2022 Meta-analysis | Sample (as reported): Not reportedDuration: Not reported | interleukin 6 (IL-6) | -0.22 (95% CI: -0.39, -0.05, p=0.010) | Benefit |
| PMID 35914448 2022 Meta-analysis | Sample (as reported): Not reportedDuration: Not reported | serum C-reactive protein (CRP) | -0.40 (95% CI: -0.56, -0.24, p<0.001) | Benefit |
| PMID 35914448 2022 Meta-analysis | Sample (as reported): Not reportedDuration: Not reported | Tumour necrosis factor α (TNFα) | -0.23 (95% CI: -0.37, -0.08, p=0.002) | Benefit |
Omega-3 (EPA/DHA) × Inflammation: the evidence base
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Role of the EPA: DHA dosing ratio in omega-3 supplements on blood fatty acid profiles and inflammation: a systematic review and meta-analysisKhabir Z, et al. · Critical reviews in food science and nutrition · 2026PMID 41568426 ↗02Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic ReviewMalcangi G, et al. · Nutrients · 2025PMID 40077632 ↗03Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-AnalysisZhang Y, et al. · Nutrients · 2025PMID 40806131 ↗04A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive functionShahinfar H, et al. · Scientific reports · 2025PMID 40836005 ↗05Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysisGhobadi H, et al. · Inflammopharmacology · 2025PMID 40839182 ↗06The effect of two anti-inflammatory dietary components, omega-3 and resveratrol, on endometriosisSienko A, et al. · Ginekologia polska · 2024PMID 37768015 ↗Community experiences
Contributors volunteered; this does not establish treatment effectiveness or population incidence.
Reported changes
No publishable community breakdown is available. This does not establish that no reports exist.