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Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are forms of vitamin B3 that the body turns into NAD+. The biochemical effect is proven: oral doses reliably raise blood NAD+. Clinical benefit in humans is not. Meta-analyses of randomised trials find no improvement in blood sugar, insulin, cholesterol, muscle mass or strength, and only a small diastolic blood-pressure signal so far.
4 of 4 results reported a benefit, from 1 published study.
1 randomised trial, 48 people
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every individual result is listed below.
See every resultSustained physical performance — cardiovascular capacity, stamina, and oxygen utilisation during prolonged exercise.
Also known as: NMN, Nicotinamide mononucleotide, NR, Nicotinamide riboside
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for NMN / NR (NAD+ precursors) in endurance.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 34238308 2021 | Randomised trial | 48 | six-week | oxygen uptake (VO2) | reported qualitatively | Benefit |
| PMID 34238308 2021 | Randomised trial | 48 | six-week | percentages of maximum oxygen uptake (VO2max) | reported qualitatively | Benefit |
| PMID 34238308 2021 | Randomised trial | 48 | six-week | power at first ventilatory threshold | reported qualitatively | Benefit |
| PMID 34238308 2021 | Randomised trial | 48 | six-week | power at second ventilatory threshold | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
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