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Phosphatidylserine for Age-Related Cognitive Decline

Phospholipid concentrated in neuronal cell membranes, now typically sourced from soy or sunflower lecithin; small trials suggest a reduced cortisol response to exercise stress and modest cognitive benefit in age-related decline.

-published research: study records
-published research: findings
Not formally gradedcertainty of the research
On this pageOverviewEvidenceCommunity outcomesRelated
Why Phosphatidylserine for Age-Related Cognitive Decline?

The connection

Gradual changes in memory, processing speed, and executive function associated with ageing.

Also known as: PS, Soy phosphatidylserine

Published research

Phosphatidylserine × Age-Related Cognitive Decline: at a glance

Every published result for this pair, extracted and audited.

Published research

Phosphatidylserine / Age-Related Cognitive Decline: publication years

What this means: Counts describe research quantity, not treatment effectiveness or certainty.

Phosphatidylserine / Age-Related Cognitive Decline: publication years (publications, count)
CategoryPublications (count)
20244
20252
← Zoom out: all evidence for PhosphatidylserineZoom out: compare compounds for Age-Related Cognitive Decline →
Published research

Phosphatidylserine × Age-Related Cognitive Decline: the evidence base

Hand-selected PubMed studies, linked to the originals.

6studies referenced
6journals
2024–2025publication range

Ordered by strength of evidence, then result direction.

01Effects of acute exercise on cognitive function: A meta-review of 30 systematic reviews with meta-analysesChang YK, et al. · Psychological bulletin · 2025PMID 39883421 ↗02Piriformis syndrome: a systematic review of case reportsMonteleone G, et al. · BMC surgery · 2025PMID 41068685 ↗03Recent advances and controversial issues in the optimal management of asymptomatic carotid stenosisParaskevas KI, et al. · Journal of vascular surgery · 2024PMID 37939746 ↗04Impact of one night of sleep restriction on sleepiness and cognitive function: A systematic review and meta-analysisWüst LN, et al. · Sleep medicine reviews · 2024PMID 38759474 ↗05The effectiveness of visual-based interventions on health literacy in health care: a systematic review and meta-analysisGalmarini E, et al. · BMC health services research · 2024PMID 38862966 ↗06A systematic review and meta-analysis of cortisol levels in Plasmodium infectionsKotepui KU, et al. · Scientific reports · 2024PMID 39107355 ↗
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Community experiences

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Reported changes

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Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.