supplement × Mental Health
Inositol for Panic Attacks
Sugar alcohol, not a true vitamin, involved in insulin signal transduction and cell membrane structure; myo-inositol is well studied for improving insulin sensitivity and ovulation in PCOS, and for reducing panic and anxiety symptoms.
3published research: study records
12published research: findings
Not formally gradedcertainty of the research
Published research
What studies found
Inositol for Panic Attacks
6 of 11 results reported a benefit, from 3 published studies.
3 randomised trials, 28 people · the chart counts everything measured
- 6 reported a benefit
- 4 no clear benefit
- 1 possible harm
Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.
- Panic attacks per weekFell by 4 vs 2.4with fluvoxamine, unit not reported1 randomised trial, compared with another treatment2001 study ↗
- Panic attack frequency and severityReported a benefitmeasurement not reportedInositol improved frequency and severity of panic attacks compared with placebo in Twenty-one (4-week).1 randomised trial1995 study ↗
- Panic attacks and agoraphobiaReported a benefitmeasurement not reportedInositol 12 g per day improved Frequency and severity of panic attacks and severity of agoraphobia compared with placebo in twenty-one (four week).1 randomised trial1997 study ↗
Also measured in these studies (8)
These were measured alongside, but they are not what this condition is about.
- ADHD symptomsReported a possible harmmeasurement not reportedInositol 200 mg/kg body weight showed harm (adverse effect) on Attention deficit disorder (ADDH) with hyperactivity symptomatology compared with placebo in Eleven children (eight week).1 randomised trial1997 study ↗
- Agoraphobia severityReported a benefitmeasurement not reportedInositol improved severity of agoraphobia compared with placebo in Twenty-one (4-week).1 randomised trial1995 study ↗
- Alzheimer's symptomsNo clear benefit foundmeasurement not reportedInositol 6 g daily did not significantly improve Therapeutic effects in Alzheimer's compared with glucose; the difference versus the comparator was not statistically established in eleven (one month each).1 randomised trial1997 study ↗
- Autism symptomsNo clear benefit foundmeasurement not reportedInositol 200 mg/kg per day did not significantly improve Autism symptoms in an uncontrolled study (no comparison group) in nine.1 randomised trial1997 study ↗
- Depression symptomsReported a benefitmeasurement not reportedInositol 12 g daily improved Hamilton Depression Scale compared with placebo in 28 (four weeks).1 randomised trial1997 study ↗
- Memory problems after ECTNo clear benefit foundmeasurement not reportedInositol 6 g daily did not significantly improve ECT-induced memory impairment in an uncontrolled study (no comparison group) in twelve (five days).1 randomised trial1997 study ↗
- OCD symptomsReported a benefitmeasurement not reportedInositol 18 g improved OCD symptoms scores compared with placebo in thirteen (six weeks each).1 randomised trial1997 study ↗
- Schizophrenia symptomsNo clear benefit foundmeasurement not reportedInositol 12 g daily did not significantly improve Schizophrenic symptoms in an uncontrolled study (no comparison group) in twelve (a month).1 randomised trial1997 study ↗
Side effects: measured in 1 result. No result reported more side effects than the comparison group.
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every result is listed below.
See every resultWhy Inositol for Panic Attacks?
The connection
Sudden episodes of intense fear with physical symptoms — racing heart, shortness of breath, dizziness.
Also known as: Myo-inositol, D-Chiro-inositol
Published research
Inositol × Panic Attacks: at a glance
Every published result for this pair, extracted and audited.
These charts count reported findings from published studies, grouped by reported benefit and study design. Study design is not a certainty grade.
Inositol / Panic Attacks: reported findings; one study may contribute several findings.
What the evidence shows
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Benefit | 7 |
| Harm / risk | 1 |
| No benefit | 4 |
Study designs behind these findings
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Randomised trial | 12 |
- Studies
- 3
| Study | Outcome | Reported result | Uncertainty (as reported) | Study duration |
|---|---|---|---|---|
| Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. (PMID 11386498) | Nausea and tiredness | Not reported | p = 0.02; p = 0.01 | 1 month |
| Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. (PMID 11386498) | Number of panic attacks per week | 4.0 (2) | p = 0.049 | 1 month |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | Attention deficit disorder (ADDH) with hyperactivity symptomatology | Not reported | Not reported | eight week |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | Autism symptoms | Not reported | Not reported | Not reported |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | ECT-induced memory impairment | Not reported | Not reported | five days |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | Frequency and severity of panic attacks and severity of agoraphobia | Not reported | Not reported | four week |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | Hamilton Depression Scale | Not reported | Not reported | four weeks |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | OCD symptoms scores | Not reported | Not reported | six weeks each |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | Schizophrenic symptoms | Not reported | Not reported | a month |
| Controlled trials of inositol in psychiatry. (PMID 9169302) | Therapeutic effects in Alzheimer's | Not reported | Not reported | one month each |
| Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. (PMID 7793450) | frequency and severity of panic attacks | Not reported | Not reported | 4-week |
| Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. (PMID 7793450) | severity of agoraphobia | Not reported | Not reported | 4-week |
Study results, as reported by the publications
Every measured outcome, one row per finding - numbers exactly as reported. Units are preserved where supplied; missing units are not inferred.
| Study and type | Reported sample and duration | Outcome measured | Reported result | What studies found |
|---|---|---|---|---|
| PMID 11386498 2001 Randomised trial | Sample (as reported): TwentyDuration: 1 month | Nausea and tiredness | Not reported (p = 0.02; p = 0.01) | Benefit |
| PMID 11386498 2001 Randomised trial | Sample (as reported): TwentyDuration: 1 month | Number of panic attacks per week | 4.0 (2) (p = 0.049) | Benefit |
| PMID 9169302 1997 Randomised trial | Sample (as reported): Eleven childrenDuration: eight week | Attention deficit disorder (ADDH) with hyperactivity symptomatology | Not reported | Harm / risk |
| PMID 9169302 1997 Randomised trial | Sample (as reported): nineDuration: Not reported | Autism symptoms | Not reported | No benefit |
| PMID 9169302 1997 Randomised trial | Sample (as reported): twelveDuration: five days | ECT-induced memory impairment | Not reported | No benefit |
| PMID 9169302 1997 Randomised trial | Sample (as reported): twenty-oneDuration: four week | Frequency and severity of panic attacks and severity of agoraphobia | Not reported | Benefit |
| PMID 9169302 1997 Randomised trial | Sample (as reported): 28Duration: four weeks | Hamilton Depression Scale | Not reported | Benefit |
| PMID 9169302 1997 Randomised trial | Sample (as reported): thirteenDuration: six weeks each | OCD symptoms scores | Not reported | Benefit |
| PMID 9169302 1997 Randomised trial | Sample (as reported): twelveDuration: a month | Schizophrenic symptoms | Not reported | No benefit |
| PMID 9169302 1997 Randomised trial | Sample (as reported): elevenDuration: one month each | Therapeutic effects in Alzheimer's | Not reported | No benefit |
| PMID 7793450 1995 Randomised trial | Sample (as reported): Twenty-oneDuration: 4-week | frequency and severity of panic attacks | Not reported | Benefit |
| PMID 7793450 1995 Randomised trial | Sample (as reported): Twenty-oneDuration: 4-week | severity of agoraphobia | Not reported | Benefit |
Published research
Inositol × Panic Attacks: the evidence base
Hand-selected PubMed studies, linked to the originals.
6studies referenced
6journals
2023–2026publication range
Ordered by strength of evidence, then result direction.
01Integrative Systematic Review on Pharmacological, Psychotherapeutic, and Neurostimulatory Treatment Options in Treatment-Resistant Anxiety DisordersSchiele MA, et al. · Psychotherapy and psychosomatics · 2026PMID 40946318 ↗02Comparison of metformin with inositol versus metformin alone in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trialsKelly FA, et al. · Endocrine · 2025PMID 39331347 ↗03Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysisMaddock RJ, et al. · Molecular psychiatry · 2025PMID 40913113 ↗04Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS GuidelinesFitz V, et al. · The Journal of clinical endocrinology and metabolism · 2024PMID 38163998 ↗05Nutrition and bipolar disorder: a systematic reviewGabriel FC, et al. · Nutritional neuroscience · 2023PMID 35608150 ↗06Polycystic ovaries and herbal remedies: A systematic reviewManouchehri A, et al. · JBRA assisted reproduction · 2023PMID 35916457 ↗Community experiences
Contributors volunteered; this does not establish treatment effectiveness or population incidence.
Reported changes
No publishable community breakdown is available. This does not establish that no reports exist.
Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.