Community observations, not medical advice.Always speak with a qualified healthcare professional.
herb × Mental Health

Saffron for Anxiety

Spice from the stigmas of Crocus sativus; its crocin and safranal compounds inhibit serotonin, dopamine, and noradrenaline reuptake, with small trials showing effects on mild-to-moderate depression comparable to low-dose SSRIs.

-published research: study records
-published research: findings
Not formally gradedcertainty of the research
On this pageOverviewEvidenceCommunity outcomesRelated
Why Saffron for Anxiety?

The connection

Generalised anxiety, social anxiety and panic disorder.

Also known as: Crocus sativus

Published research

Saffron × Anxiety: at a glance

Every published result for this pair, extracted and audited.

Published research

Saffron / Anxiety: publication years

What this means: Counts describe research quantity, not treatment effectiveness or certainty.

Saffron / Anxiety: publication years (publications, count)
CategoryPublications (count)
20242
20254
← Zoom out: all evidence for SaffronZoom out: compare compounds for Anxiety →
Published research

Saffron × Anxiety: the evidence base

Hand-selected PubMed studies, linked to the originals.

6studies referenced
6journals
2024–2025publication range

Ordered by strength of evidence, then result direction.

01Effect of Saffron Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment of Depression and Anxiety: A Meta-analysis of Randomized Controlled TrialsShafiee A, et al. · Nutrition reviews · 2025PMID 38913392 ↗02Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysisCheng YC, et al. · Psychological medicine · 2025PMID 40314175 ↗03Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysisMaddock RJ, et al. · Molecular psychiatry · 2025PMID 40913113 ↗04Effects of Different Cannabinoid Formulations on Anxiety-Related Disorders, and Tourette Syndrome: A Systematic Review and Meta-AnalysisRaminelli AO, et al. · Cannabis and cannabinoid research · 2025PMID 40956670 ↗05Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic ReviewMohammed SYM, et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024PMID 37953193 ↗06New horizons for the study of saffron (Crocus sativus L.) and its active ingredients in the management of neurological and psychiatric disorders: A systematic review of clinical evidence and mechanismsHan S, et al. · Phytotherapy research : PTR · 2024PMID 38424688 ↗
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Community experiences

Contributors volunteered; this does not establish treatment effectiveness or population incidence.

Reported changes

No publishable community breakdown is available. This does not establish that no reports exist.

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Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.