About Anxiety — Mental Health.
Generalised anxiety, social anxiety and panic disorder.
Tried something for Anxiety? Share how it went — only ever published as part of a group of 10+.
Figures as the studies reported them.
Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.
Also measured alongside: Stress levels (reported a benefit); Overall sleep (reported a benefit); Quality of life (mixed results); and 7 more.
Every resultNo figure given: Anxiety symptoms (reported a benefit).
Also measured alongside: Depression symptoms (reported a benefit); Planning and problem-solving skills (reported a benefit); Sleep quality (reported a benefit); and 1 more.
Every resultAlso measured alongside: Depression symptoms (no clear benefit).
Every resultWhat this means: Bars count reported findings, not treatment effectiveness or certainty.
One study may report several findings or appear in more than one pairing. Counts do not show the size of an effect. Comparable numerical estimates are not established for this summary.
| Compound and condition | Findings (count) | Studies (count) | Reported results (finding counts) | How sure? |
|---|---|---|---|---|
| Ashwagandha | 15 | 3 | Benefit: 11; no benefit: 4; harm: 0; unclear: 0; not recorded / unrecognised: 0 | Not formally graded |
| L Theanine | 9 | 2 | Benefit: 9; no benefit: 0; harm: 0; unclear: 0; not recorded / unrecognised: 0 | Not formally graded |
| Inositol | 3 | 1 | Benefit: 0; no benefit: 3; harm: 0; unclear: 0; not recorded / unrecognised: 0 | Not formally graded |
Strongest evidence first.
| Compound | Study designs | Reported findings |
|---|---|---|
| AshwagandhaResearch score 60/100 · Moderate | 2 systematic reviews/meta-analyses + 1 randomised trial — 3 studies | 11/15 outcomes showed benefit
|
| L TheanineResearch score 64/100 · Moderate | 1 systematic review/meta-analysis + 1 randomised trial — 2 studies | 9/9 outcomes showed benefit
|
| InositolResearch score 0/100 · Mixed/Weak | 1 systematic review/meta-analysis — 1 study | 0/3 outcomes showed benefit
|
We publish anxiety results only once at least 10 people report on the same compound, so no individual report is ever shown.
Used something for anxiety? Share how it went — only ever published in a group of 10 or more.
Add your outcomeEvery study behind the numbers above is linked next to its result.
Strongest evidence first.
01Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysisMaddock RJ, et al. · Molecular psychiatry · 2025Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 40913113 ↗02Effects of Different Cannabinoid Formulations on Anxiety-Related Disorders, and Tourette Syndrome: A Systematic Review and Meta-AnalysisRaminelli AO, et al. · Cannabis and cannabinoid research · 2025Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 40956670 ↗03Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic ReviewMohammed SYM, et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 37953193 ↗04Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancyMinozzi S, et al. · The Cochrane database of systematic reviews · 2024Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 38682758 ↗05Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysisHan K, et al. · Psychiatry research · 2024Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 38924898 ↗06Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysisFatima K, et al. · Human psychopharmacology · 2024Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 39083548 ↗07Therapeutic Evaluation of Unani Medicine, Including Single Drugs and Polyherbal Formulations with Special Reference to Neurodegenerative DisordersImran S, et al. · Alternative therapies in health and medicine · 2024Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 39212516 ↗08Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysisArumugam V, et al. · Explore (New York, N.Y.) · 2024Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 39348746 ↗09The effects of L-theanine supplementation on the outcomes of patients with mental disorders: a systematic reviewMoshfeghinia R, et al. · BMC psychiatry · 2024Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 39633316 ↗10Plant-derived nootropics and human cognition: A systematic reviewLorca C, et al. · Critical reviews in food science and nutrition · 2023Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 34978226 ↗11Nutrition and bipolar disorder: a systematic reviewGabriel FC, et al. · Nutritional neuroscience · 2023Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35608150 ↗12In Search of Biomarkers to Guide Interventions in Autism Spectrum Disorder: A Systematic ReviewParellada M, et al. · The American journal of psychiatry · 2023Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 36475375 ↗13Baclofen for alcohol use disorderAgabio R, et al. · The Cochrane database of systematic reviews · 2023Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 36637087 ↗14Interventions for generalized anxiety disorderByrne GJ · Current opinion in psychiatry · 2023Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 36705012 ↗15Cannabis-based medicines and medical cannabis for adults with cancer painHäuser W, et al. · The Cochrane database of systematic reviews · 2023Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 37283486 ↗16Cannabis and cannabinoid use in autism spectrum disorder: a systematic reviewSilva EAD Junior, et al. · Trends in psychiatry and psychotherapy · 2022Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 34043900 ↗17Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studiesSolmi M, et al. · Molecular psychiatry · 2022Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 34079068 ↗18Effects of Cannabis in Parkinson's Disease: A Systematic Review and Meta-AnalysisUrbi B, et al. · Journal of Parkinson's disease · 2022Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 34958046 ↗19Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) TaskforceSarris J, et al. · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35311615 ↗20Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysisZhang W, et al. · Pharmacological research · 2022Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35378276 ↗21A meta-analysis of conditioned fear generalization in anxiety-related disordersCooper SE, et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35501429 ↗22Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysisKishi T, et al. · Translational psychiatry · 2022Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35764619 ↗23Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indicationsBilbao A, et al. · BMC medicine · 2022Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35982439 ↗24Impact of COVID-19 on Mental Health in Adolescents: A Systematic ReviewJones EAK, et al. · International journal of environmental research and public health · 2021Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 33802278 ↗25Pharmacotherapy for trichotillomaniaHoffman J, et al. · The Cochrane database of systematic reviews · 2021Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 34582562 ↗26Cannabidiol as a Treatment for Mood Disorders: A Systematic ReviewPinto JV, et al. · Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 31830820 ↗27Medicinal cannabis for psychiatric disorders: a clinically-focused systematic reviewSarris J, et al. · BMC psychiatry · 2020Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 31948424 ↗28Psychotherapy or medication for depression? Using individual symptom meta-analyses to derive a Symptom-Oriented Therapy (SOrT) metric for a personalised psychiatryKappelmann N, et al. · BMC medicine · 2020Meta-Analysis · matched via Anxiety · open-access full text · PubMed record (CORPUS-A)
PMID 32498707 ↗29Anti-Aβ agents for mild to moderate Alzheimer's disease: systematic review and meta-analysisLu L, et al. · Journal of neurology, neurosurgery, and psychiatry · 2020Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 33046560 ↗30Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-AnalysisShinjyo N, et al. · Journal of evidence-based integrative medicine · 2020Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 33086877 ↗31Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysisGobbi G, et al. · JAMA psychiatry · 2019Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 30758486 ↗32GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidenceSavage K, et al. · Phytotherapy research : PTR · 2018Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 29168225 ↗33Insomnia in Alcohol-Dependent Patients: Prevalence, Risk Factors and Acamprosate Effect: An Individual Patient Data Meta-AnalysisPerney P, et al. · Alcohol and alcoholism (Oxford, Oxfordshire) · 2018Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 29617889 ↗34Baclofen for alcohol use disorderMinozzi S, et al. · The Cochrane database of systematic reviews · 2018Meta-Analysis · matched via Anxiety · PubMed record (CORPUS-A)
PMID 30484285 ↗35Green tea effects on cognition, mood and human brain function: A systematic reviewMancini E, et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2017Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 28899506 ↗36Herbal remedies for anxiety - a systematic review of controlled clinical trialsErnst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2006Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 16428031 ↗37Valerian for anxiety disordersMiyasaka LS, et al. · The Cochrane database of systematic reviews · 2006Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 17054208 ↗38Inositol for depressive disordersTaylor MJ, et al. · The Cochrane database of systematic reviews · 2004Systematic Review · matched via Anxiety · PubMed record (CORPUS-A)
PMID 15106232 ↗39Ketogenic diet is less effective in ameliorating depression and anxiety in obesity than Mediterranean diet: A pilot study for exploring the GUT-brain axisMela V, et al. · Brain, behavior, and immunity · 2026Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 41197688 ↗40The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trialFries LR, et al. · Scientific reports · 2025Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 40175540 ↗41Low-intensity transcranial focused ultrasound amygdala neuromodulation: a double-blind sham-controlled target engagement study and unblinded single-arm clinical trialBarksdale BR, et al. · Molecular psychiatry · 2025Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 40275098 ↗42Effect of caffeine and cannabidiol (CBD) co-administration on Δ9-tetrahydrocannabinol (Δ9-THC) subjective effects, performance impairment, and pharmacokineticsStrickland JC, et al. · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 40962814 ↗43Performance-enhancing effects of caffeine and L-Theanine among Iranian elite wrestlers: a focus on cognitive and specific physical performanceRazazan R, et al. · Journal of the International Society of Sports Nutrition · 2025Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 40977612 ↗44Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trialSilva EAD Junior, et al. · Trends in psychiatry and psychotherapy · 2024Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35617670 ↗45Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical StudyChandra Shekhar H, et al. · Advances in therapy · 2024Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 37899385 ↗46Examination of the effects of cannabidiol on menstrual-related symptomsFerretti ML, et al. · Experimental and clinical psychopharmacology · 2024Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 38451730 ↗47Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trialVelasquez ACA, et al. · Oral and maxillofacial surgery · 2024Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 38743126 ↗48Impact of L-theanine and L-tyrosine on markers of stress and cognitive performance in response to a virtual reality based active shooter training drillMcAllister MJ, et al. · Stress (Amsterdam, Netherlands) · 2024Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 38975711 ↗49A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free SupplementKolobaric A, et al. · Nutrients · 2023Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 37686820 ↗50Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot StudyRizzo R, et al. · Nutrients · 2022Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35215501 ↗51Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled StudyNoah L, et al. · Nutrients · 2022Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 35565828 ↗52Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled TrialYoung LM, et al. · Nutrients · 2022Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 36501109 ↗53Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trialRoh D, et al. · Phytotherapy research : PTR · 2019Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 30632220 ↗54An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled studyLopresti AL, et al. · Medicine · 2019Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 31517876 ↗55affron(®) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trialKell G, et al. · Complementary therapies in medicine · 2017Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 28735826 ↗56Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in HumansMineo L, et al. · Neuropsychobiology · 2017Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 29035887 ↗57Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover TrialWhite DJ, et al. · Nutrients · 2016Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 26797633 ↗58An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and moodBenson S, et al. · Phytotherapy research : PTR · 2014Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 23788517 ↗59Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adultsSathyanarayanan V, et al. · Psychopharmacology · 2013Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 23354535 ↗60Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled studyTubaki BR, et al. · Journal of alternative and complementary medicine (New York, N.Y.) · 2012Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 22784349 ↗61Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiolFusar-Poli P, et al. · The international journal of neuropsychopharmacology · 2010Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 19775500 ↗62Clinical predictors of outcome from an Australian pharmacological relapse prevention trialMorley KC, et al. · Alcohol and alcoholism (Oxford, Oxfordshire) · 2010Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 20952764 ↗63Naltrexone versus acamprosate in the treatment of alcohol dependence: A multi-centre, randomized, double-blind, placebo-controlled trialMorley KC, et al. · Addiction (Abingdon, England) · 2006Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 16968347 ↗64Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extractNadulski T, et al. · Therapeutic drug monitoring · 2005Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 16306858 ↗65The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjectsStough C, et al. · Psychopharmacology · 2001Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 11498727 ↗66United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcoholChick J, et al. · Alcohol and alcoholism (Oxford, Oxfordshire) · 2000Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 10787394 ↗67Acamprosate and relapse prevention in the treatment of alcohol dependence: a placebo-controlled studyTempesta E, et al. · Alcohol and alcoholism (Oxford, Oxfordshire) · 2000Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 10787398 ↗68Inositol treatment of post-traumatic stress disorderKaplan Z, et al. · Anxiety · 1996Randomized Controlled Trial · matched via Anxiety · PubMed record (CORPUS-A)
PMID 9160600 ↗69Cannabidiol reduces anxiety in simulated public speaking: A randomised trialBergamaschi MM et al. · Neuropsychopharmacology · 2024300mg CBD significantly reduced anxiety during simulated public speaking vs placebo.
PMID 22928017 ↗70Ashwagandha root extract for stress and anxiety: A systematic reviewPratte MA et al. · J Altern Complement Med · 2024Systematic review of 7 RCTs finding ashwagandha significantly reduced anxiety vs placebo.
PMID 32630791 ↗71The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performanceGuo S, et al. · Frontiers in nutrition · 2024Journal Article · matched via Anxiety · PubMed record (CORPUS-A)
PMID 39155932 ↗72Oral magnesium supplementation reduces subjective anxiety in adultsBoyle NB et al. · Nutrients · 2023Magnesium supplementation (300mg) improved subjective anxiety in mildly anxious adults.
PMID 29065490 ↗73L-Theanine reduces stress-related symptoms in adults: A randomised controlled trialHidese S et al. · Nutrients · 2023200mg L-theanine daily for 4 weeks reduced anxiety scores and improved sleep quality.
PMID 32531951 ↗74Can Ashwagandha Benefit the Endocrine System?-A ReviewWiciński M, et al. · International journal of molecular sciences · 2023Journal Article · matched via Anxiety · PubMed record (CORPUS-A)
PMID 38003702 ↗75Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspectsMandlik Ingawale DS, et al. · Journal of dietary supplements · 2021Journal Article · matched via Anxiety · PubMed record (CORPUS-A)
PMID 32242751 ↗76Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and InsomniaSpeers AB, et al. · Current neuropharmacology · 2021Journal Article · matched via Anxiety · PubMed record (CORPUS-A)
PMID 34254920 ↗Position is not a recommendation. Scores summarise published studies only.