Vitamin D3 for Bone Health
Fat-soluble vitamin synthesised in skin from UVB exposure and activated by the liver and kidneys; regulates calcium and phosphate absorption for bone health and modulates immune and mood pathways via vitamin D receptors.
Vitamin D3 for Bone Health
0 of 3 results reported a benefit, from 1 published study.
1 randomised trial, 25,871 people · the chart counts everything measured
- 3 no clear benefit
Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.
- Fractures (all types)No clear difference2% lower rate1 randomised trial2022 study ↗
- Hip fracturesNo clear difference1% higher rate1 randomised trial2022 study ↗
- Non-spine fracturesNo clear difference3% lower rate1 randomised trial2022 study ↗
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every result is listed below.
See every resultThe connection
Bone density, osteoporosis prevention, fracture recovery.
Also known as: Cholecalciferol
Vitamin D3 × Bone Health: at a glance
Every published result for this pair, extracted and audited.
These charts count reported findings from published studies, grouped by reported benefit and study design. Study design is not a certainty grade.
Vitamin D3 / Bone Health: reported findings; one study may contribute several findings.
What the evidence shows
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| No benefit | 3 |
Study designs behind these findings
What this means: Counts describe research quantity, not treatment effectiveness or certainty.
| Category | Findings (count) |
|---|---|
| Randomised trial | 3 |
- Studies
- 1
| Study | Outcome | Reported result | Uncertainty (as reported) | Study duration |
|---|---|---|---|---|
| Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. (PMID 35939577) | hip fractures | Not reported | hazard ratio, 1.01; 95% CI, 0.70 to 1.47; P=0.96 | median follow-up of 5.3 years |
| Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. (PMID 35939577) | nonvertebral fractures | Not reported | hazard ratio, 0.97; 95% CI, 0.87 to 1.07; P=0.50 | median follow-up of 5.3 years |
| Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. (PMID 35939577) | total fractures | Not reported | hazard ratio, 0.98; 95% confidence interval [CI], 0.89 to 1.08; P=0.70 | median follow-up of 5.3 years |
Study results, as reported by the publications
Every measured outcome, one row per finding - numbers exactly as reported. Units are preserved where supplied; missing units are not inferred.
| Study and type | Reported sample and duration | Outcome measured | Reported result | What studies found |
|---|---|---|---|---|
| PMID 35939577 2022 Randomised trial | Sample (as reported): 25,871Duration: median follow-up of 5.3 years | hip fractures | Not reported (hazard ratio, 1.01; 95% CI, 0.70 to 1.47; P=0.96) | No benefit |
| PMID 35939577 2022 Randomised trial | Sample (as reported): 25,871Duration: median follow-up of 5.3 years | nonvertebral fractures | Not reported (hazard ratio, 0.97; 95% CI, 0.87 to 1.07; P=0.50) | No benefit |
| PMID 35939577 2022 Randomised trial | Sample (as reported): 25,871Duration: median follow-up of 5.3 years | total fractures | Not reported (hazard ratio, 0.98; 95% confidence interval [CI], 0.89 to 1.08; P=0.70) | No benefit |
Vitamin D3 × Bone Health: the evidence base
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Vitamin D's Impact on Cancer Incidence and Mortality: A Systematic ReviewWimalawansa SJ · Nutrients · 2025PMID 40732958 ↗02Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025PMID 40797337 ↗03Population-based interventions for preventing falls and fall-related injuries in older peopleLewis SR, et al. · The Cochrane database of systematic reviews · 2024PMID 38180112 ↗04The effect of vitamin D supplementation on depression: a systematic review and dose-response meta-analysis of randomized controlled trialsGhaemi S, et al. · Psychological medicine · 2024PMID 39552387 ↗05The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trialsMikola T, et al. · Critical reviews in food science and nutrition · 2023PMID 35816192 ↗06What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysisManoj P, et al. · International journal of older people nursing · 2023PMID 35842938 ↗Community experiences
Contributors volunteered; this does not establish treatment effectiveness or population incidence.
Reported changes
No publishable community breakdown is available. This does not establish that no reports exist.