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Memory, mental clarity, and overall brain health. Critical for healthy ageing and peak performance.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Creatine Monohydrate | 1 systematic review/meta-analysis outcome | Memory improved with SMD 0.88 vs placebo in older adults (66-76 years) over 5 days to 24 weeks.5/4 outcomes showed benefit | PMID 35984306 |
| Ginkgo Biloba | 1 systematic review/meta-analysis outcome | EGb761 improved activities of daily living by -0.36 versus placebo over 22-26 weeks.4/2 outcomes showed benefit | PMID 25114079 |
| Vitamin B12 | 1 systematic review/meta-analysis outcome | Vitamin B12 supplementation showed no significant benefit for cognitive function compared with placebo in people with dementia and low B12.2/2 outcomes showed benefit | PMID 12918012 |
| Lion Mane | 3 randomised trial outcomes | Participants performed quicker on the Stroop task vs placebo in 41 people at 60 minutes.3/3 outcomes showed benefit | PMID 38004235 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Randomized Controlled Trial · matched via Cognitive Function · PubMed record (CORPUS-A)
PMID 40854087 ↗02Ginkgo biloba for cognitive impairment and dementiaWieland LS, et al. · The Cochrane database of systematic reviews · 2026Systematic Review · matched via Cognitive Function · PubMed record (CORPUS-A)
PMID 41641880 ↗03A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive functionShahinfar H, et al. · Scientific reports · 2025Systematic Review · matched via Cognitive Function · PubMed record (CORPUS-A)
PMID 40836005 ↗04Creatine Supplementation in Combat Sport Athletes: A Narrative Systematic ReviewAshtary-Larky D, et al. · Journal of dietary supplements · 2025Systematic Review · matched via Cognitive Function · PubMed record (CORPUS-A)
PMID 40755023 ↗05Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic reviewMenon A, et al. · Frontiers in nutrition · 2025Systematic Review · matched via Cognitive Function · PubMed record (CORPUS-A)
PMID 40959699 ↗06Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysisSystematic Review · matched via Cognitive Function · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Significantly improved (3g daily, 16 weeks)
Adults with mild cognitive impairment · Double-blind trial · PMID 17425936 ↗Moderate evidenceImproved02Episodic memory — ImprovedImproved with DHA-rich supplementation
Adults with mild memory complaints · Systematic review · PMID 32069340 ↗Strong evidenceImproved03Cognitive function — ImprovedModest benefit
Dementia patients · Meta-analysis · PMID 28295450 ↗Strong evidenceImprovedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.