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Post-workout soreness, muscle repair, DOMS, and recovery between training sessions.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Creatine Monohydrate | 2 systematic review/meta-analysis outcomes | Creatine significantly reduced CK concentration at 48, 72, and 96 hours vs placebo.8/2 outcomes showed benefit | PMID 34472118 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Journal Article · matched via Muscle Recovery · PubMed record (CORPUS-A)
PMID 41829950 ↗02Cordycepin ameliorates lipopolysaccharide-challenged C2C12 myotube shrinkage by regulating sodium channel kinetics and inhibiting the protein degradation pathwayZhang X, et al. · International immunopharmacology · 2026Journal Article · matched via Muscle Recovery · PubMed record (CORPUS-A)
PMID 42492235 ↗03Current Evidence and Practical Considerations for Adaptogen Use in Exercise Recovery, Training Adaptation, and Exercise Performance in Athletes: A Narrative ReviewKsiążek A · Nutrients · 2026Journal Article · matched via Muscle Recovery · PubMed record (CORPUS-A)
PMID 42588175 ↗04The Effects of Creatine Monohydrate Supplementation on Recovery from Eccentric Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial Considering Sex and Age DifferencesYamaguchi S, et al. · Nutrients · 2025Randomized Controlled Trial · matched via Muscle Recovery · PubMed record (CORPUS-A)
PMID 40507040 ↗05Creatine for muscle recovery: A systematic reviewKreider RB et al. · J Int Soc Sports Nutr · 2024Creatine monohydrate reduces muscle damage and soreness, speeds recovery between training sessions.
PMID 30060440 ↗Systematic Review · matched via Muscle Recovery · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Reduced; faster recovery between training sessions (monohydrate)
Training adults · Systematic review · PMID 30060440 ↗Strong evidenceReduced02Muscle recovery and cramping — ImprovedImproved recovery; reduced cramping
Athletes · Meta-analysis · PMID 33627718 ↗Strong evidenceImprovedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.