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Difficulty falling asleep, staying asleep, or poor sleep quality. Insomnia affects ~30% of adults.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Melatonin | 2 systematic review/meta-analysis outcomes | Melatonin increased sleep duration by 44 min compared with placebo in children with ASD.8/2 outcomes showed benefit | PMID 32112261 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Open the original papers, check their methods, and discuss what is relevant with a qualified professional.
Journal Article · matched via Sleep · PubMed record (CORPUS-A)
PMID 41901246 ↗02Exploring Phytoleads and Traditional Herbal Therapies: A Comparative Review on Stress ManagementRathee S, et al. · Current pharmaceutical design · 2026Journal Article · matched via Sleep · PubMed record (CORPUS-A)
PMID 41919431 ↗03Effects of combined GABA and L-theanine supplementation on sleep quality: an exploratory studyKonno H, et al. · European review for medical and pharmacological sciences · 2026Journal Article · matched via Sleep · PubMed record (CORPUS-A)
PMID 41636292 ↗04The effects of oral cannabidiol supplementation on blood pressure in adults: a systematic review of randomised controlled trialsRoberts A, et al. · Journal of cannabis research · 2026Systematic Review · matched via Sleep · PubMed record (CORPUS-A)
PMID 42321899 ↗05A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer's DiseaseRosenberg PB, et al. · The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Randomized Controlled Trial · matched via Sleep · PubMed record (CORPUS-A)
PMID 41350162 ↗06Randomized Controlled Trial · matched via Sleep · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Reduced by ~7 minutes
Adults with sleep complaints · Systematic review & meta-analysis · PMID 23702256 ↗Strong evidenceReduced02Overall sleep quality — ImprovedImproved
Adults with sleep complaints · Systematic review & meta-analysis · PMID 23702256 ↗Strong evidenceImproved03Subjective sleep quality — ImprovedImproved with 500mg daily for 8 weeks
Elderly with insomnia · Randomised controlled trial · PMID 23853647 ↗Moderate evidenceImproved04Sleep satisfaction — ImprovedImproved satisfaction, reduced night waking (400mg daily, 8 weeks)
Adults with sleep complaints · Double-blind randomised trial · PMID 33799711 ↗Moderate evidenceImprovedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.