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Low testosterone symptoms — low libido, fatigue, muscle loss, mood changes.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Zinc | 2 systematic review/meta-analysis outcomes | PDE5 inhibitors improved erectile function scores by 10.65 compared to placebo.4/3 outcomes showed benefit | PMID 21154382 |
| Fenugreek | 1 randomised trial outcome | Estradiol levels significantly increased with fenugreek (Libifem) compared with placebo over 8 weeks.4/1 outcomes showed benefit | PMID 25914334 |
| Shilajit | Observational evidence | Shilajit increased normal sperm count by +18.9% compared to baseline; there was no control group.5/1 outcomes showed benefit | PMID 20078516 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Open the original papers, check their methods, and discuss what is relevant with a qualified professional.
Systematic Review · matched via Testosterone · PubMed record (CORPUS-A)
PMID 41518979 ↗02Safety and Efficacy of TruBlk™ Shilajit Resin Supplementation on Physical Performance and Blood Biomarkers in Healthy Adults: A 28-Day Open-Label Pilot StudyYadav D, et al. · Cureus · 2026Journal Article · matched via Testosterone · PubMed record (CORPUS-A)
PMID 41613504 ↗03Ashwagandha increases testosterone in men: A randomised trialLopresti AL et al. · Evid Based Complement Alternat Med · 2023300mg KSM-66 twice daily for 8 weeks increased testosterone by 17% and reduced cortisol by 19%.
PMID 31531186 ↗04Zinc and testosterone in men: A reviewPrasad AS et al. · Nutrition · 2023Zinc deficiency reduces testosterone; supplementation restores it in deficient men.
PMID 9700595 ↗05Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women: A randomized, double-blinded, placebo-controlled studyKhanna A, et al. · Journal of food biochemistry · 2020Randomized Controlled Trial · matched via Testosterone · PubMed record (CORPUS-A)
PMID 33025616 ↗06Effects of surgical and chemical sterilization on the behavior of free-roaming male dogs in Puerto Natales, ChileRandomized Controlled Trial · matched via Testosterone · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Increased by 17%; cortisol reduced by 19% (300mg twice daily, 8 weeks)
Men · Randomised controlled trial · PMID 31531186 ↗Moderate evidenceImproved02Testosterone — ImprovedRestored in deficient men with supplementation
Zinc-deficient men · Review · PMID 9700595 ↗Weak evidenceImprovedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.