Community observations, not medical advice.Always speak with a qualified healthcare professional.
Physical Health

Acne

About Acne — Physical Health.

Inflammatory skin condition causing spots, pimples, and cysts. Affects face, back, and chest.

1studies analysed
1compounds with evidence
Randomised trialstrongest evidence
Where research is strongest
  1. Zinc 22
Add your outcome — free & pseudonymous

Tried something for Acne? Share how it went — only ever published as part of a group of 10+.

2linked compounds
13linked studies
0published community reports

Headline results for Acne.

Figures as the studies reported them.

Colour keyReported a benefitNo clear benefitUnclearPossible harmAmber is for highlights, such as where the most research is. It never means a result was good.

1of 2

Zinc

1 of 2 results reported a benefit

1 randomised trial, 52 people

  • Other acne spotsNo clear benefit foundmeasurement not reportedZinc did not benefit comedones, papules, infiltrates, or cysts compared to placebo.1 randomised trial1978 study ↗

No figure given: Pus-filled spots (pustules) (reported a benefit).

Every result

Where the evidence is concentrated.

Published research

Acne: findings by compound

What this means: Bars count reported findings, not treatment effectiveness or certainty.

One study may report several findings or appear in more than one pairing. Counts do not show the size of an effect. Comparable numerical estimates are not established for this summary.

View the full data table
Published research: reported directions by pairing
Compound and conditionFindings (count)Studies (count)Reported results (finding counts)How sure?
Zinc21Benefit: 1; no benefit: 1; harm: 0; unclear: 0; not recorded / unrecognised: 0Not formally graded

Degree of benefit for Acne

Strongest evidence first.

Published research: Acne. Study design is not a certainty grade.
CompoundStudy designsReported findings
ZincResearch score 22/100 · Mixed/Weak1 randomised trial — 1 study1/2 outcomes showed benefit
  • Other acne lesionsNo clear benefit found — measurement not reportedno benefit1978 study ↗
    Exact figuresn=52 · Follow-up: 12-week · Sample (as reported): 52 · Recorded unit: Not reported · Zinc sulfate in acne vulgaris. · Randomized Controlled Trial · rct · PMID 153730
  • PustulesReported a benefit — measurement not reportedbenefit1978 study ↗
    Exact figuresn=52 · Follow-up: 12-week · Sample (as reported): 52 · Recorded unit: Not reported · Zinc sulfate in acne vulgaris. · Randomized Controlled Trial · rct · PMID 153730
Important: This page reflects observational, aggregate-only community reporting and independent published research. It is not medical advice, and it does not claim any compound treats, cures, or is effective for any condition. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or treatment.

No community reports published yet.

We publish acne results only once at least 10 people report on the same compound, so no individual report is ever shown.

  • Zinc

    Research saysResearch score 22/100 · Mixed/Weak1 of 1 study reported at least one benefit
    People reportNot published yet — needs 10 or more reports

Used something for acne? Share how it went — only ever published in a group of 10 or more.

Add your outcome

Peer-reviewed research.

Every study behind the numbers above is linked next to its result.

12 more papers, not summarised above

Strongest evidence first.

01Dietary patterns, metabolic pathways and metainflammation in hidradenitis suppurativa: a systematic reviewCelik E, et al. · Frontiers in immunology · 2026

Systematic Review · matched via Acne · PubMed record (CORPUS-A)

PMID 42233037 ↗
02Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic ReviewShields A, et al. · JAMA dermatology · 2023

Systematic Review · matched via Acne · PubMed record (CORPUS-A)

PMID 37878272 ↗
03Non-pharmacologic approaches for hidradenitis suppurativa - a systematic reviewHendricks AJ, et al. · The Journal of dermatological treatment · 2021

Systematic Review · matched via Acne · PubMed record (CORPUS-A)

PMID 31106609 ↗
04Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acneLiu H, et al. · The Cochrane database of systematic reviews · 2020

Meta-Analysis · matched via Acne · PubMed record (CORPUS-A)

PMID 32356369 ↗
05Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysisYee BE, et al. · Dermatologic therapy · 2020

Meta-Analysis · matched via Acne · PubMed record (CORPUS-A)

PMID 32860489 ↗
06Minocycline for acne vulgaris: efficacy and safetyGarner SE, et al. · The Cochrane database of systematic reviews · 2012

Meta-Analysis · matched via Acne · PubMed record (CORPUS-A)

PMID 22895927 ↗
07Acne vulgarisPurdy S, et al. · BMJ clinical evidence · 2011

Systematic Review · matched via Acne · PubMed record (CORPUS-A)

PMID 21477388 ↗
08Acne vulgarisPurdy S, et al. · BMJ clinical evidence · 2008

Systematic Review · matched via Acne · PubMed record (CORPUS-A)

PMID 19450306 ↗
09Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face StudyQueille-Roussel C, et al. · Journal of cosmetic dermatology · 2026

Randomized Controlled Trial · matched via Acne · PubMed record (CORPUS-A)

PMID 41487026 ↗
10Changes in androgens during treatment with four low-dose contraceptivesCoenen CM, et al. · Contraception · 1996

Randomized Controlled Trial · matched via Acne · PubMed record (CORPUS-A)

PMID 8689882 ↗
11Comparative evaluation of the androgenicity of four low-dose, fixed-combination oral contraceptivesCoenen CM, et al. · International journal of fertility and menopausal studies · 1995

Randomized Controlled Trial · matched via Acne · PubMed record (CORPUS-A)

PMID 8574256 ↗
12Influence of gestodene and desogestrel as components of low-dose oral contraceptives on the pharmacokinetics of ethinyl estradiol (EE2), on serum CBG and on urinary cortisol and 6 beta-hydroxycortisolHammerstein J, et al. · Contraception · 1993

Randomized Controlled Trial · matched via Acne · PubMed record (CORPUS-A)

PMID 8462317 ↗
Important: Studies vary in quality and relevance. We do not interpret them or give medical advice.