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Inflammatory skin condition causing spots, pimples, and cysts. Affects face, back, and chest.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Zinc | 1 randomised trial outcome | Zinc did not benefit comedones, papules, infiltrates, or cysts compared to placebo.1/1 outcomes showed benefit | PMID 153730 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Randomized Controlled Trial · matched via Acne · PubMed record (CORPUS-A)
PMID 41487026 ↗02Dietary patterns, metabolic pathways and metainflammation in hidradenitis suppurativa: a systematic reviewCelik E, et al. · Frontiers in immunology · 2026Systematic Review · matched via Acne · PubMed record (CORPUS-A)
PMID 42233037 ↗03Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic ReviewShields A, et al. · JAMA dermatology · 2023Systematic Review · matched via Acne · PubMed record (CORPUS-A)
PMID 37878272 ↗04Non-pharmacologic approaches for hidradenitis suppurativa - a systematic reviewHendricks AJ, et al. · The Journal of dermatological treatment · 2021Systematic Review · matched via Acne · PubMed record (CORPUS-A)
PMID 31106609 ↗05Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysisYee BE, et al. · Dermatologic therapy · 2020Meta-Analysis · matched via Acne · PubMed record (CORPUS-A)
PMID 32860489 ↗06Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acneLiu H, et al. · The Cochrane database of systematic reviews · 2020Meta-Analysis · matched via Acne · PubMed record (CORPUS-A)