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Persistent pain lasting longer than 3 months. Can stem from injury, inflammation, or nervous system dysfunction.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Cannabis THC | 2 systematic review/meta-analysis outcomes | Cannabis-based medicines increased 30% pain relief to 39% versus 33% with placebo in 1586 participants.5/2 outcomes showed benefit | PMID 29513392 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)
PMID 41429020 ↗02Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic ReviewMohammed SYM, et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)
PMID 37953193 ↗03Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral NeuropathyD'Souza RS, et al. · Current pain and headache reports · 2023Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)
PMID 37058254 ↗04Cannabis-Based Products for Chronic Pain : A Systematic ReviewMcDonagh MS, et al. · Annals of internal medicine · 2022Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)
PMID 35667066 ↗05Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indicationsBilbao A, et al. · BMC medicine · 2022Meta-Analysis · matched via Chronic Pain · PubMed record (CORPUS-A)
PMID 35982439 ↗06Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosisFilippini G, et al. · The Cochrane database of systematic reviews · 2022Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)