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Insulin resistance, pre-diabetes, type 2 diabetes, and metabolic syndrome.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Fenugreek | 5 systematic review/meta-analysis outcomes | Fenugreek lowered fasting glucose compared to control interventions, with a mean change difference of -0.96 mmol/l.25/6 outcomes showed benefit | PMID 24438170 |
| Berberine | 2 systematic review/meta-analysis outcomes | Fasting plasma glucose reduced by 0.54 mmol/L vs control in 2,313 patients.15/3 outcomes showed benefit | PMID 30393248 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Systematic Review · matched via Blood Sugar · PubMed record (CORPUS-A)
PMID 42433212 ↗02The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trialMansour A, et al. · European journal of nutrition · 2025Randomized Controlled Trial · matched via Blood Sugar · PubMed record (CORPUS-A)
PMID 39998703 ↗03Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical TrialJi L, et al. · JAMA network open · 2025Randomized Controlled Trial · matched via Blood Sugar · PubMed record (CORPUS-A)
PMID 40029660 ↗04Does berberine impact anthropometric, hepatic, and metabolic parameters in patients with metabolic dysfunction-associated fatty liver disease? Randomized, double-blind placebo-controlled trialKoperska A, et al. · Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2024Randomized Controlled Trial · matched via Blood Sugar · PubMed record (CORPUS-A)
PMID 39042390 ↗05The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-analysis of Randomized Controlled TrialsNazari A, et al. · Clinical therapeutics · 2024Systematic Review · matched via Blood Sugar · PubMed record (CORPUS-A)
PMID 38016844 ↗Berberine (500mg 3x daily) lowered HbA1c similarly to metformin over 3 months.
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Lowered similarly to metformin (500mg three times daily, 3 months)
Type 2 diabetes patients · Randomised controlled trial · PMID 18790740 ↗Moderate evidenceReduced02Insulin sensitivity and ovulation — ImprovedImproved insulin sensitivity and ovulation rates
PCOS patients · Meta-analysis · PMID 32134487 ↗Strong evidenceImprovedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.