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Acne, ageing skin, elasticity, hydration, wound healing, and overall skin appearance.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Vitamin C | 1 systematic review/meta-analysis outcome | Topical ascorbic acid improved photodamage compared to placebo in a small study; the abstract gives no effect size.2/1 outcomes showed benefit | PMID 15674885 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Open the original papers, check their methods, and discuss what is relevant with a qualified professional.
Systematic Review · matched via Skin Health · PubMed record (CORPUS-A)
PMID 41184662 ↗02Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate MatterIvarsson J, et al. · Journal of cosmetic dermatology · 2025Randomized Controlled Trial · matched via Skin Health · PubMed record (CORPUS-A)
PMID 40642809 ↗03Granulomatous Reactions From Microneedling: A Systematic Review of the LiteratureFriedmann DP, et al. · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2025Systematic Review · matched via Skin Health · PubMed record (CORPUS-A)
PMID 39584690 ↗04Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsMyung SK, et al. · The American journal of medicine · 2025Systematic Review · matched via Skin Health · PubMed record (CORPUS-A)
PMID 40324552 ↗05Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysisDanessa G, et al. · Indian journal of dermatology, venereology and leprology · 2025Systematic Review · matched via Skin Health · PubMed record (CORPUS-A)
PMID 40826844 ↗Systematic Review · matched via Skin Health · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Improved after 8+ weeks of hydrolysed collagen
Adults supplementing collagen · Systematic review · PMID 31253804 ↗Strong evidenceImproved02Inflammatory acne lesions — ReducedReduced by approximately 50%
Acne patients · Systematic review & meta-analysis · PMID 30697370 ↗Strong evidenceReducedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.