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Chronic stress, burnout, high cortisol. Distinct from anxiety — stress is the response, anxiety is the reaction.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Numbers come from the trial reports themselves — see each study via its PMID.
| Compound | Evidence strength | What trials suggest | Study |
|---|---|---|---|
| Ashwagandha | 2 randomised trial outcomes | Ashwagandha significantly reduced fatigue symptoms compared to placebo in adults over 12 weeks.5/2 outcomes showed benefit | PMID 37740662 |
| Reishi | 1 randomised trial outcome | Ganoderma did not significantly change antioxidant status or lymphocyte subsets compared to placebo.1/1 outcomes showed benefit | PMID 21801467 |
Audited published findings per compound. Dark green = benefit findings; full bar = all findings. Drill into a pair for the breakdown.
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking.
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Open the original papers, check their methods, and discuss what is relevant with a qualified professional.
Systematic Review · matched via Stress · PubMed record (CORPUS-A)
PMID 41644067 ↗02Efficacy and safety of Ashwagandha (Withania somnifera) root extract in pregnant women: a prospective, randomized, comparative, open-label, 12-week studyAjgaonkar A, et al. · Frontiers in global women's health · 2026Clinical Trial · matched via Stress · PubMed record (CORPUS-A)
PMID 41767760 ↗03Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complicationsXin Y, et al. · Frontiers in pharmacology · 2026Systematic Review · matched via Stress · PubMed record (CORPUS-A)
PMID 42147328 ↗04Potential Bioactive Function of Microbial Metabolites as Inhibitors of Tyrosinase: A Systematic ReviewBarcenas-Giraldo S, et al. · International journal of molecular sciences · 2026Systematic Review · matched via Stress · PubMed record (CORPUS-A)
PMID 41596661 ↗05Transcriptome-based meta-analysis of drought stress regulatory genes in tomatoMurtaza M, et al. · BMC plant biology · 2025Meta-Analysis · matched via Stress · PubMed record (CORPUS-A)
PMID 41068586 ↗06Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future PerspectivesSystematic Review · matched via Stress · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Reduced by 28% (300mg twice daily, 8 weeks)
Adults under chronic stress · Double-blind randomised trial · PMID 28479013 ↗Moderate evidenceReduced02Perceived stress — ReducedStress scores reduced by 44% (300mg twice daily, 8 weeks)
Adults under chronic stress · Double-blind randomised trial · PMID 28479013 ↗Moderate evidenceReduced03Exercise-induced cortisol response — ReducedBlunted by ~20% (600mg)
Exercising adults · Randomised trial · PMID 26491131 ↗Moderate evidenceReducedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.